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Neuroscience Graduate Student Research

 

Baker Lab

Linghai Kong

Linghai Kong

RESEARCH INTEREST 

I am interested in understanding the glutamatergic basis of neuropsychiatric disorders, such as addiction and schizophrenia.  My thesis work centers on pituitary adenylate cyclase-activating peptide (PACAP), a pleiotropic neuropeptide expressed exclusively by neurons. We have found that PACAP is capable of coordinating glutamate transmission within neuron-astrocyte network, and that PACAP signaling in the nucleus accumbens influences cocaine-seeking behavior of rats. Currently, I am investigating the causal relationship between these two major findings, and the impact of cocaine on PACAP signaling.

 

PUBLICATIONS

Kong L, Albano R, Madayag A, Raddatz N, Mantsch JR, Choi S, Lobner D, Baker DA. Pituitary Adenylate Cyclase-Activating Polypeptide Orchestrates Neuronal Regulation of the Astrocytic Glutamate Releasing Mechanism System xc-. J Neurochem. 2016 Feb 6. doi: 10.1111/jnc.13566. [Epub ahead of print] PMID: 26851652

 

Lutgen V, Kong L, Kau KS, Madayag A, Mantsch JR, Baker DA. Time course of cocaine-induced behavioral and neurochemical plasticity. Addict Biol. 2014 Jul; 19(4):529-38. doi: 10.1111/j.1369-1600.2012.00493.x. Epub 2012 Sep 12. PMID: 22970924

Lutgen V, Resch J, Qualmann K, Raddatz NJ, Panhans C, Olander EM,

 

Kong L, Choi S, Mantsch JR, Baker DA. Behavioral assessment of acute inhibition of system xc - in rats. Psychopharmacology (Berl). 2014 May 15. [Epub ahead of print] PMID: 24828877

 

Lutgen V, Qualmann K, Resch J, Kong L, Choi S, Baker DA. Reduction in phencyclidine induced sensorimotor gating deficits in the rat following increased system xc(-) activity in the medial prefrontal cortex. Psychopharmacology (Berl). 2013 Apr;226(3):531-40. doi: 10.1007/s00213-012-2926-3. Epub 2012 Nov 29. PMID: 23192314

 

CONFERENCES

2011 - 2015: Society for Neuroscience (SfN)

 

HONORS AND AWARDS

2012-2015:     Graduate and Professional Student Research Travel Award (Marquette University, Graduate School)

2014:     Richard W. Jobling Fellowship (Marquette University, Graduate School)

 

Evan Hess

Evan Hess

 

 

Blackmore Lab

Ben Callif

Ben Callif

RESEARCH INTEREST

 

In mammals, neurons in the periphery have a remarkable capacity to regenerate compared to neurons in the brain. Therefore, the primary goal of the Blackmore lab is to understand and manipulate the environmental and genetic factors that control axon growth. I am focused on using high-throughput screening in vitro to discover genes that play a role in axon regeneration. I can then manipulate gene expression in vivo to determine if our target genes affect functional recovery following spinal cord injury.

 

PUBLICATIONS

 

Evans, J.A., Suen, T.C., Callif, B.L., Mitchell, A.S., Castanon-Cervantes, O., Baker, K.M., Kloehn, I., Baba, K., Teubner, B.J.W., Ehlen, J.C., Paul, K.N., Bartness, T.J., Tosini, G., Leise, T. & Davidson, A.J. (2015) Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body. BMC Biology. ​Forthcoming.

 

Simpson, M.T., Venkatesh, I., Callif, B.L., Thiel, L.K., Coley, D.M., Winsor, K.N., Wang, Z., Kramer, A.A., Lerch, J.K. & Blackmore, M.G. (2015) The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons. ​​​Molecular and Cellular Neuroscience. Forthcoming.

 

 

Audra Kramer

Audra Kramer

RESEARCH INTEREST

 

 

 

Choi Lab

Matt Hurley

Matt Hurley

RESEARCH INTEREST

My research focuses on understanding how the neuropeptide PACAP (Pituitary Adenylate-Cyclase Activating Polypeptide) differentially regulates hunger- and palatability-driven feeding in the hypothalamus and ventral striatum. To study this we employ a variety of preclinical rodent feeding paradigms which allows us to better examine these feeding motives independent of one another.

PUBLICATIONS

Hurley MM, Resch JM, Maunze B, Frenkel MM, Baker DA, Choi S. N-acetylcysteine decreases binge eating in a rodent model. Int J Obes (Lond). 2016 Jul;40(7):1183-6. dio: 10.1038/ijo.2016.31. Epub 2016 Feb 15.

Hurley MM, Maunze B, Block ME, Frenkel MM, Reilly MJ, Kim E, Chen Y, Li Y, Baker DA, Liu Q and Choi S (2016). Pituitary Adenylate-Cyclase Activating Polypeptide Regulates Hunger- and Palatability-Induced Binge Eating. Front. Neurosci. 10:383. doi: 10.3389/fnins.2016.00383

CONFERENCES
2014, 2015: Society For Neuroscience

HONORS & AWARDS
2016 Richard W. Jobling Fellowship (Marquette University, Graduate School)

 

 

Gilmartin Lab

Adam Kirry

Adam Kirry

RESEARCH INTEREST

 

 

 

Mantsch Lab

Beth Doncheck

Beth Doncheck

RESEARCH INTEREST
I am investigating how exactly stress and ovarian hormones act to enhance relapse vulnerability in cocaine addicts. Both the stress hormone corticosterone and the ovarian hormone 17β-estradiol have been shown to mobilize endogenous cannabinoids which, in turn, can render the drug-seeking circuitry more excitable in response to ordinarily subthreshold relapse triggers.  My research focuses on how these phenomena occur specifically within the prefrontal cortex, and how they may differ between the sexes.

 

PUBLICATIONS

McReynolds JR, Doncheck EM, Vranjkovic O, Ganzman GS, Baker DA, Hillard CJ, and Mantsch JR.  CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. Psychopharmacology 2016 Jan; 233(1):99-109.

 

Hanlon EC, Tasali E, Leproult R, Stuhr KL, Doncheck E, de Wit H, Hillard CJ, and Van Cauter E. Sleep restriction enhances the daily rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol. Sleep 2015 November 19.

 

Hanlon EC, Tasali E, Leproult R, Stuhr KL, Doncheck EM, de Wit H, Hillard CJ, and Van Cauter E.  Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. The Journal of Clinical Endocrinology & Metabolism 2015 January; 100(1):220-6.

 

Twining RC, Tuscher JJ, Doncheck EM, Frick KM, and Mueller DT. Estradiol enhances extinction of cocaine seeking. Learning & Memory 2013 May 15;20(6):300-6

 

CONFERENCES
2012 - 2016: Society for Neuroscience (SfN)

2014 - 2016: Neurobiology of Stress Workshop

2015: International Cannabinoid Research Society (ICRS)

2012, 2014: Molecular & Cellular Cognition Society

2011: Pavlovian Society Meeting

 

HONORS & AWARDS

2016: 2016 Summer Research Fellowship (Marquette University, Graduate School)

2016: 2016 Richard W. Jobling Fellowship (Marquette University, Graduate School)

2015: 2015 ICRS Student Poster Presentation (ICRS, Graduate student level)

2015: Travel Award for 2015 ICRS (ICRS, Graduate student level)

2014: Travel Award for 2014 SfN (Marquette University, Graduate School)

2014: 2014 Graduate Student Poster Presentations (Milwaukee SfN Chapter)

 

 

Oliver Vranjkovic

Oliver Vranjkovic

RESEARCH INTEREST

 

The goal of my research is to identify the neurobiological pathway responsible for stress-induced relapse in recovering cocaine addicts. Specifically, my research examines a beta adrenergic receptor-regulated pathway originating in the bed nucleus of the stria terminalis that releases the neuropeptide CRF into the ventral tegmental area. Currently I’m examining whether CRF-mediated activation of mesocortical DA projections to the prelimbic cortex is also necessary for stress-induced cocaine seeking.

 

PUBLICATIONS

 

Figueroa-Guzman Y, Mueller C, Vranjkovic O, Wisniewski S, Yang Z, et al. 2011. Oral administration of levo-tetrahydropalmatine attenuates reinstatement of extinguished cocaine seeking by cocaine, stress or drug-associated cues in rats. Drug and alcohol dependence 116: 72-9

 

Graf EN, Hoks MA, Baumgardner J, Sierra J, Vranjkovic O, et al. 2011. Adrenal activity during repeated long-access cocaine self-administration is required for later CRF-Induced and CRF-dependent stressor-induced reinstatement in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 36: 1444-54

 

Mantsch JR, Vranjkovic O, Twining RC, Gasser PJ, McReynolds JR, Blacktop JM. 2014. Neurobiological mechanisms that contribute to stress-related cocaine use. Neuropharmacology 76 Pt B: 383-94

 

Mantsch JR, Weyer A, Vranjkovic O, Beyer CE, Baker DA, Caretta H. 2010a. Involvement of noradrenergic neurotransmission in the stress- but not cocaine-induced reinstatement of extinguished cocaine-induced conditioned place preference in mice: role for beta-2 adrenergic receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 35: 2165-78

 

Mantsch JR, Wisniewski S, Vranjkovic O, Peters C, Becker A, et al. 2010b. Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in rats. Pharmacology, biochemistry, and behavior 97: 310-6

 

McReynolds JR, Vranjkovic O, Thao M, Baker DA, Makky K, et al. 2014. Beta-2 adrenergic receptors mediate stress-evoked reinstatement of cocaine-induced conditioned place preference and increases in CRF mRNA in the bed nucleus of the stria terminalis in mice. Psychopharmacology

 

Vaughn LK, Mantsch JR, Vranjkovic O, Stroh G, Lacourt M, et al. 2012. Cannabinoid receptor involvement in stress-induced cocaine reinstatement: potential interaction with noradrenergic pathways. Neuroscience 204: 117-24

 

Vranjkovic O, Hang S, Baker DA, Mantsch JR. 2012. beta-adrenergic receptor mediation of stress-induced reinstatement of extinguished cocaine-induced conditioned place preference in mice: roles for beta1 and beta2 adrenergic receptors. The Journal of pharmacology and experimental therapeutics 342: 541-51

 

 

CONFERENCES

 

2010-2014 Society for Neuroscience

2014 Neurobiology of Stress Workshop  

 

 

Wheeler Lab

Chung Lung Chang

Chung Lung Chang

RESEARCH INTEREST

 

I am interested in the roles of the ventral pallidum as an output nucleus that receives signals from the mesocorticolimbic reward circuitry.  My current project applies electrophysiological techniques to examine the correlation between hedonic responses and changes in neuronal activity in this nucleus.

Mykel Robble

Mykel Robble

RESEARCH INTEREST

 

I am interested in motivated behavior, and disease states, like drug addiction, that impact healthy motivation. Specifically, my research focuses on the impact of stressful stimuli, and stimuli that elicit a negative affective state, on dopaminergic neurotransmission and relapse. 

 

First Year Graduate Students

Matthew Herbst

Kayla Rohr

 

 

Mitchell Spring

To help in determining the best fit of student and mentor, first-year students do three laboratory rotations. During the rotations, students are temporary members of the laboratories whose research appears to be of greatest interest to them. Before the end of the student's second semester, an advisor who guides both research and selection of coursework is chosen by mutual agreement between faculty and student.

 

 



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