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NEUROSCIENCE GRADUATE PROGRAM

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Neuroscience Graduate Student Research

 

Baker Lab

Linghai Kong

Linghai Kong

RESEARCH INTEREST

 

My research interest is to explore the role that system Xc- plays in cocaine addiction, specifically, the targeting of system Xc- to glutamate receptors other than mGluR2/3, and the impact of changes in system Xc- on cocaine addictive rats.

Jack Cleland

Jack Cleland

RESEARCH INTEREST

 

My research goals are centered around the attempt to understand the relevance of extrasynaptic and nonvesicular glutamtergic transmission in the pathogenesis of schizophrenia.

 

Choi Lab

Matt Hurley

Matt Hurley

RESEARCH INTEREST

 

 

 

Gilmartin Lab

Adam Kirry

Adam Kirry

RESEARCH INTEREST

 

 

 

Lobner Lab

Rebecca Albano

Rebecca Albano

RESEARCH INTEREST

 

The cystine/glutamate antiporter (system xc-) mediates the transport of cystine into the cell in exchange for releasing glutamate into the extrasynaptic space.  The function of system xc- makes it likely to play an important role in regulating neuronal survival and death. My research focuses on the regulation of system xc-.  Specifically, I am looking at how system xc- is regulated in SOD1-G93A mutant mice​ and at how regulating system xc- effects neuronal death.

 

PUBLICATIONS

 

Albano R, Liu X, Lobner D. (2013) Regulation of system x(c)- in the SOD1-G93A mouse model of ALS. Exp Neurol. Dec; 250:69-73.

Liu X, Albano R, Lobner D. (2014) FGF-2 induces neuronal death through up regulation of system xc-. Brain Res. Feb 14;1547:25-33.

 

CONFERENCES

 

2011 Society for Neuroscience annual conference, Washington D.C.

 

2012 Society for Neuroscience annual conference, New Orleans, LA. Presented: The regulation of system xc- in the SOD1-G93A mouse model of ALS

 

2013 Society for Neuroscience annual conference, San Diego, CA. Presented: Regulation of system xc- by intracellular cysteine

 

HONORS AND AWARDS​

 

2013 Richard W. Jobling Fellowship, Marquette University

 

 

Mantsch Lab

Beth Doncheck

Beth Doncheck

RESEARCH INTEREST


I am interested in investigating how exactly, on the cellular and molecular level, stress confers relapse vulnerability to cocaine addicts. Stress hormones are known to mobilize endogenous cannabinoids, which in turn are capable of modulating neurotransmission within brain regions implicated in drug-seeking behavior. My research focuses on these molecular interactions within one such pivotal brain region, the prefrontal cortex, and how these phenomena may differ between genders.

PUBLICATIONS


Twining RC, Tuscher JJ, Doncheck EM, Frick KM, & Mueller D. (2013) 17β-Estradiol is necessary for extinction of cocaine seeking in female rats. Learn. Mem. 2013 20: 300-306.

CONFERENCES


2011 Pavlovian Society Meeting, Milwaukee, WI. Presented: Extinction of cocaine seeking reduces elevated bFGF expression and is enhanced by neutralizing bFGF in the medial prefrontal cortex.


2012 Society for Neuroscience, New Orleans, LA. Presented: Acquisition of cocaine seeking increases expression of basic fibroblast growth factor in the medial prefrontal cortex and nucleus accumbens, an effect reversed by extinction.


2014 Neurobiology of Stress Workshop, Cincinnati, OH. Presented: Prefrontal cortical endocannabinoid-mediated stress-potentiated reinstatement of cocaine seeking.


2014 Society for Neuroscience, Washington, D.C. Presented: Relationship between stress-potentiated reinstatement of cocaine seeking and prefrontal cortical endocannabinoid signaling.

 

 

Oliver Vranjkovic

Oliver Vranjkovic

RESEARCH INTEREST

 

The goal of my research is to identify the neurobiological pathway responsible for stress-induced relapse in recovering cocaine addicts. Specifically, my research examines a beta adrenergic receptor-regulated pathway originating in the bed nucleus of the stria terminalis that releases the neuropeptide CRF into the ventral tegmental area. Currently I’m examining whether CRF-mediated activation of mesocortical DA projections to the prelimbic cortex is also necessary for stress-induced cocaine seeking.

 

PUBLICATIONS

 

Figueroa-Guzman Y, Mueller C, Vranjkovic O, Wisniewski S, Yang Z, et al. 2011. Oral administration of levo-tetrahydropalmatine attenuates reinstatement of extinguished cocaine seeking by cocaine, stress or drug-associated cues in rats. Drug and alcohol dependence 116: 72-9

 

Graf EN, Hoks MA, Baumgardner J, Sierra J, Vranjkovic O, et al. 2011. Adrenal activity during repeated long-access cocaine self-administration is required for later CRF-Induced and CRF-dependent stressor-induced reinstatement in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 36: 1444-54

 

Mantsch JR, Vranjkovic O, Twining RC, Gasser PJ, McReynolds JR, Blacktop JM. 2014. Neurobiological mechanisms that contribute to stress-related cocaine use. Neuropharmacology 76 Pt B: 383-94

 

Mantsch JR, Weyer A, Vranjkovic O, Beyer CE, Baker DA, Caretta H. 2010a. Involvement of noradrenergic neurotransmission in the stress- but not cocaine-induced reinstatement of extinguished cocaine-induced conditioned place preference in mice: role for beta-2 adrenergic receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 35: 2165-78

 

Mantsch JR, Wisniewski S, Vranjkovic O, Peters C, Becker A, et al. 2010b. Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in rats. Pharmacology, biochemistry, and behavior 97: 310-6

 

McReynolds JR, Vranjkovic O, Thao M, Baker DA, Makky K, et al. 2014. Beta-2 adrenergic receptors mediate stress-evoked reinstatement of cocaine-induced conditioned place preference and increases in CRF mRNA in the bed nucleus of the stria terminalis in mice. Psychopharmacology

 

Vaughn LK, Mantsch JR, Vranjkovic O, Stroh G, Lacourt M, et al. 2012. Cannabinoid receptor involvement in stress-induced cocaine reinstatement: potential interaction with noradrenergic pathways. Neuroscience 204: 117-24

 

Vranjkovic O, Hang S, Baker DA, Mantsch JR. 2012. beta-adrenergic receptor mediation of stress-induced reinstatement of extinguished cocaine-induced conditioned place preference in mice: roles for beta1 and beta2 adrenergic receptors. The Journal of pharmacology and experimental therapeutics 342: 541-51

 

 

CONFERENCES

 

2010-2014 Society for Neuroscience

2014 Neurobiology of Stress Workshop  

 

 

Peoples Lab

Yulin Zhao

Yulin Zhao

RESEARCH INTEREST

 

My Project is focusing on defining the molecular mechanisms and sites of action of alcohols on the N-methyl-d-aspartate (NMDA) receptor, which is one of neurotransmitter-gated ion channels. Most of my work is focusing on the role of residues in the NR2B subunit of NMDA receptor in the regulation of receptor ion channel gating and alcohol sensitivity.

 

Wheeler Lab

Chung Lung Chang

Chung Lung Chang

RESEARCH INTEREST

 

I am interested in the roles of the ventral pallidum as an output nucleus that receives signals from the mesocorticolimbic reward circuitry.  My current project applies electrophysiological techniques to examine the correlation between hedonic responses and changes in neuronal activity in this nucleus.

Mykel Robble

Mykel Robble

RESEARCH INTEREST

 

I am interested in motivated behavior, and disease states, like drug addiction, that impact healthy motivation. Specifically, my research focuses on the impact of stressful stimuli, and stimuli that elicit a negative affective state, on dopaminergic neurotransmission and relapse. 

 

First Year Graduate Students

Ben Callif

Evan Hess

To help in determining the best fit of student and mentor, first-year students do three laboratory rotations. During the rotations, students are temporary members of the laboratories whose research appears to be of greatest interest to them. Before the end of the student's second semester, an advisor who guides both research and selection of coursework is chosen by mutual agreement between faculty and student.

 

 



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