Graduate Courses

Also see Marquette University Graduate Bulletin

BIOL 5101. Biochemistry and the Molecular Basis of Biology. 3 cr. hrs.

Major themes in biochemistry are examined in the context of mammalian physiology. Topics include: Protein structure and enzyme catalysis, carbohydrate and lipid metabolism in relation to energy production, protein and nucleic acid synthesis, and the nature of the genetic code. 3 hrs. lec., disc.

BIOL 5102. Experimental Molecular Biology. 3 cr. hrs.

Purification, characterization and molecular analysis of proteins, nucleic acids, lipids and other biomolecules with emphasis on standard techniques widely used in research laboratories. 1 hr. lec., 4 hrs. lab. Prereq: BIOL 4101 or equiv.

BIOL 5201. Genomics and Bioinformatics. 3 cr. hrs.

The analysis of gene structure and genetic regulation in selected prokaryotes and plant and animal systems, as well as transgenic organisms. Introduction to the principles of bioinformatics and proteomics as applied to genome comparisons and protein structure and function. Models and algorithms for predictions of the biological properties of genetically modified neucleotide sequences and proteins.

BIOL 5703. Exercise Physiology. 3 cr. hrs.

Study of the effects of acute and chronic exercise on selected organ systems. Particular emphasis will be placed on muscle, cardiovascular, respiratory, and environmental physiology.

BIOL 5806. Immunobiology. 3 cr. hrs.

Cellular and molecular mechanisms of the immune response. Nature of antigens and antibodies and their interactions. Special topics include complement, immediate and delayed hypersensitivity, transplantation and tumor immunobiology, immunosuppression, and immunological tolerance. 3 hrs. lec., disc.

BIOL 6001. Radioisotope Safety. 2 cr. hrs.

Ionizing radiation: proper safety procedures in the independent use of radioisotopes and current regulatory guidelines and licensing procedures. Prereq: BIOL 1002 and CHEM 1002; or BIOL 1009 and CHEM 1002; or cons. of dept. ch.

BIOL 8101. Protein Structure and Function. 2 cr. hrs.

Advanced protein biochemistry stressing methodology and primary literature. Topics include: structural and chemical properties of amino acids, peptides and proteins; protein folding and assembly; protein-protein and protein-ligand interactions; enzyme kinetics and regulation; and the determination of protein structure. Uses examples from glycolytic and gluconeogenic metabolic pathways to highlight the structural basis for catalysis and regulation. Prereq: BIOL 4101/5101 or equiv.; or cons. of instr.

BIOL 8102. Biochemistry and Function of Nucleic Acids. 2 cr. hrs.

The biochemistry of RNA and DNA with emphasis on biological function and evolution. Specific topics include: nucleic acid structure, biophysical properties, biosynthesis, and molecular function. Prereq: BIOL 4101/5101 or cons. of instr.

BIOL 8201. Developmental Genetics and Epigenetics. 3 cr. hrs.

Analysis of genetic and epigenetic influences on development, looking at specific examples from yeast, plant and animal model organisms. Topics include: genetics of flower development, yeast mating type switching, DNA methylation, genomic imprinting, chromatin remodeling, permutation and prions. Prereq: BIOL 2201 and 2301 or equiv.

BIOL 8202. Principles of Eukaryotic Genetics. 2 cr. hrs.

Genetics of eukaryotic model organisms with a focus on genetic approaches to the analysis of contemporary biological problems. Eukaryotic chromosome structure and function. Prereq: BIOL 2201 or equiv.

BIOL 8301. Imaging and Cytoskeletons. 2 cr. hrs.

Discusses the principles of cytoskeleton and molecular motors and modern imaging tools developed for the studies of cellular mechanisms.. Prereq: BIOL 2301 or equiv.

BIOL 8302. Protein Trafficking and Organelle Identity in Eukaryotic Cells. 2 cr. hrs. An in-depth analysis of protein trafficking and organelle identity in eukaryotic cells. Discusses, in detail, mechanisms of protein translocation across biological membranes and the genetic and biochemical analysis of protein sorting to diverse organelles. Prereq: BIOL 2301 or equiv.

BIOL 8501. Molecular and Cellular Signaling. 2 cr. hrs.

Comprehensive survey of the major neurotransmitter systems including biochemical synthesis and degradation, receptors and intracellular signaling pathways. Emphasizes modern laboratory techniques and primary literature. Prereq: Cons. of instr.

BIOL 8502. Systems Neuroscience. 2 cr. hrs.

Comprehensive survey of nervous system function at the systems level and includes motor, sensory and regulatory systems. Prereq: Cons. of instr.

BIOL 8504. Advanced Survey in Neuroscience. 1 cr. hr.

An introduction to current neuroscience literature with a focus on research at Marquette. Prereq: Cons. of instr.

BIOL 8506. Cellular Neurophysiology. 2 cr. hrs.

Biophysical properties of membranes and membrane-bound proteins. In-depth study of electrotonic properties of membranes, electrical potentials, voltage-dependent and ligand-dependent ion channels. Emphasizes techniques and data interpretation. Prereq: Cons. of instr.

BIOL 8520. Behavioral Neuroendocrinology. 2 cr. hrs.

Examines neuroendocrine systems as they relate to behavioral processes and their underlying neurobiological mechanisms with emphasis on the contribution of neuroendocrine dysfunction to neuropsychiatric disease. Prereq: Cons. of inst.

BIOL 8530. Glutamate Neurotransmission. 2 cr. hrs.

Reviews critical aspects of glutamatergic signaling including an overview of glutamate receptors, transporter, and release mechanisms. The contribution of abnormal glutamatergic neurotransmission is discussed in light of a number of pathological states including stroke and schizophrenia. Students integrate course material into a novel research proposal. Prereq: Cons. of inst.

BIOL 8601. Advanced Developmental Biology. 2 cr. hrs.

Examines fundamental principles of developmental biology as they relate to embryonic and adult stem cells. Includes: origin of stem cells, regulation of stem cell niches, pluripotency and differentiation, relationship to cancer and experimental approaches to stem cell research. Also includes discussion of recent advances in stem cell biology. Prereq: BIOL 2301 or equiv.; or BIOL 3601 or equiv.

BIOL 8603. Cell and Molecular Biology of Early Development. 2 cr. hrs.

Study of the cellular and molecular mechanisms underlying the specification of cell fate in a variety of model organisms including fruit flies, nematodes, mice and zebra fish. Emphasizes genetic, biochemical and molecular techniques used in studying these complex systems. Prereq: BIOL 2301 or equiv.; or BIOL 3601 or equiv.

BIOL 8702. Muscle Biology. 2 cr. hrs.

Topics covered include: skeletal, cardiac and smooth muscle relative to their regulation, structure and function. Emphasizes similarities and differences between these three muscle types with regard to structural organizations, composition, mechanics and kinetics. In addition, covers development, regulation and disease states. Emphasizes critical reading or primary scientific literature.Prereq: BIOL 3701 or equiv.

BIOL 8704. Cellular Homeostasis. 2 cr. hrs.

Detailed study of the proteins and pathways involved in the maintenance of cell volume, pH, and ionic balance, including the analysis of the function of plasma membrane transporter and channel proteins. The emphasis will be on eukaryotic cells, but prokaryotic cells will also be convered. Prereq: BIOL 2301 or equiv., or cons. of instr.

BIOL 8801. Prokaryotic Molecular Genetics. 2 cr. hrs.

Basic principles of bacterial genetics and regulation of gene expression. Points of emphasis: 1) how genetics and regulation shape and are shaped by the biology of the organism, 2) principles that are important to all biologists, including the manipulation of bacteria in genetic cloning and protein production, 3) application of genetics to elucidate cell physiology and biochemistry. Prereq: BIOL 3801 or BIOL 4101 or BIOL 8102 or an equiv. of any of these; or cons. of instr.

BIOL 8802. Microbiology in the Environment. 2 cr. hrs.

The detection of microbial diversity, activity, growth and abundance in the environment using molecular methods. Involves examples from literature. Prereq: BIOL 3801 or equiv. or cons. of instr.

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