Dr. Ren received her M.S., M.D., and Ph.D. degrees from HuaZhong University of Science & Technology (formerly Tongji Medical University) in China. She has studied the effects of alcohol on neurotransmitter receptors since 1999, when she was a Visiting Fellow in the National Institutes of Health. Dr. Ren has been at Marquette University since 2004.
Education
- M.D. - HuaZhong University of Science & Technology
- M.S. - HuaZhong University of Science & Technology
- Ph.D. - HuaZhong University of Science & Technology
Selected Publications
- Ren, H., Zhou YL., Dwyer, D. S., and Peoples, R. W.: Interactions among positions in the third and fourth Membrane- associated domains at the intersubunit interface of the N-Methyl-D-Aspartate Receptor Forming Sites of alcohol action. J. Biol. Chem. 287, 27302-12 (2012)
- Salous, A.K., Ren, H., Lamb, K.A., Hu, XQ., Lipsky R.H. and Peoples, R.W.: Differential actions of ethanol and trichloreoethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A(NR2A) subunit. Birt. J Pharmacol 158, 1395 – 1404 （2009）
- Ren, H., Salous, A. K., Paul, J. M., Lamb, K. A., Dwyer, D. S., and Peoples, R. W.: Functional interactions of alcohol-sensitive sites in the N-methyl-D-aspartate receptor M3 and M4 domains. J. Biol. Chem. 283, 8250-8257 (2008)
- Liu, Y. W., Luo, J. L., Ren, H., Peoples, R. W., Ai, Y. X., Liu, L. J., Pang, Y. P., Li, Z. W., Han, Y. F. and Li, C. Y.: Inhibition of NMDA-gated ion channels by bis(7)-tacrine: Whole-cell and single-channel studies. Neuropharmacology 54, 1086-1094 (2008)
- Ren, H., Salous, A.K., Pail, J.M., Lipsky, R.H. and Peoples, R.W.: Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action. Br. J. Pharmacol. 151, 749-757 (2007)
- Li, C., Carlier, P. R., Ren, H., Kan, K. K., Hui, K., Wang, H., Li, W., Li, Z., Xiong, K., Clement, E. C., Xue, H., Liu, X., Li, M., Pang, Y., and Han, Y.: Alkylene tether-length dependent γ-aminobutyric acid type A receptor competitive antagonism by tacrine dimmers. Neuropharmacology 52, 436-443 (2007)
- Hu, X. Q., Sun, H., Peoples, R. W., Hong, R., and Zhang, L.: An Interaction Involving an Arginine Residue in the Cytoplasmic Domain of the 5-HT3A Receptor Contributes to Receptor Desensitization Mechanism. J. Biol. Chem. 281, 21781-21788(2006)
- Honse, Y., Ren, H., Lipsky, R. H., and Peoples, R. W.: Sites in the fourth membrane-associated domain regulate alcohol sensitivity of the NMDA receptor. Neuropharmacology 46, 647-654(2004)
- Ren, H., Honse, Y., and Peoples, R. W.: A Site of Alcohol Action in the Fourth Membrane-associated Domain of the N-Methyl-D-aspartate Receptor. J. Biol. Chem. 278, 48815-48820 (2003)
- Ren, H., Honse, Y., Karp, B. J., Lipsky, R. H., and Peoples, R. W.: A Site in the Fourth Membrane-associated Domain of the N-Methyl-D-aspartate Receptor Regulates Desensitization and Ion Channel Gating. J. Biol. Chem. 278, 276-283(2003)
- Peoples, R. W. and Ren, H.: Inhibition of N-Methyl-D-aspartate Receptors by Straight-Chain Diols: Implications for the Mechanism of the Alcohol Cutoff Effect. Mol. Pharmacol. 61, 169-176(2002)
Contact Biomedical Sciences
Department of Biomedical Sciences
College of Health Sciences
Schroeder Complex, 426
P.O. Box 1881
Milwaukee, WI 53201-1881
Phone: (414) 288-7251
Fax: (414) 288-6564
