Dr. Siebenlist received his Ph.D. from the Medical College of Wisconsin in 1984. He held a joint Postdoctoral Fellowship at The Blood Center of Southeastern Wisconsin and The Hemostasis Research Laboratory at Sinai Samaritan Medical Center where he began his studies on hemostasis. He joined the faculty at Marquette University in August of 1993.
Hemostasis is a complex series of cell/cell, cell/protein, and protein/protein interactions designed to stem blood loss. Fibrinogen is a tridomainal disulfide linked plasma protein comprised of two symmetrical halves. Each half composed of three polypeptide chains termed Aα (red), Bβ (blue), and γ (green). Human fibrinogen can be separated into two major fractions by DEAE chromatography, fibrinogen 1 (‘peak 1 fibrinogen’) and fibrinogen 2 (‘peak 2 fibrinogen’).