Professor James Kincaid

 

James R. Kincaid, Ph.D.
Professor, Analytical Chemistry
(414) 288-3539
E-mail: james.kincaid@mu.edu

Biography
Professor Kincaid obtained his B.S. degree in 1970 from Xavier University and his Ph.D. degree from Marquette University in 1974. His interests in the spectroscopy of bioinorganic molecules led him to postdoctoral research at Princeton University, where he was an NIH fellow. In 1978, he joined the faculty at the University of Kentucky as an assistant professor, before returning to Marquette University as Associate Professor in 1984. He held the title of Wehr Professor from 1993 to 1997.

Research Fields
Resonance Raman and Time-Resolved Resonance Raman Spectroscopy; structure/function relationships in heme proteins and model compounds; structure and photochemistry of transition metal complexes of interest as components of solar energy conversion devices.

A major project of continuing interest to our group involves the study of the functionally diverse heme proteins. In an attempt to elucidate the molecular mechanisms by which the various proteins interact with the heme group to effectively regulate this impressively varied reactivity, we are engaged in a multifaceted approach to investigate the structural alterations and functional consequences associated with subtle and selective manipulation of the protein: heme interface, including the study of site-directed mutants and chemically modified hemes. In addition to studies of stable states we are also using time-resolved resonance Raman (TR3) techniques to investigate the detailed structure of shortlived reaction intermediates. Such a multifaceted approach provides the student with an opportunity to become familiar with a large number of techniques including: the use of sophisticated Raman spectrometers as well as continuous and pulsed lasers; IR and NMR spectroscopy; routine separation methods, including GC/MS; protein purification methods; some organic synthesis, enzyme analysis and bacterial cell culturing techniques.

In our second major program we are studying the photophysical properties of tris (2,2'bipyridine) ruthenium(II), [Ru(bpy)3]2+. Great interest in this and related complexes is generated by the fact that collectively they provide a readily accessible and versatile class of compounds which is suitable for systematic investigation of the structural and electronic factors which influence fundamental photophysical processes and photochemistry. This interest is augmented by the intriguing possibility that such species have potential value as components of practical solar energy conversion devices.   Realization of this potential will require incorporation of these sensitizers into organized molecular assemblies which include electron transfer relay components as well as catalysts appropriate for multi-electron transfer conversions.  Certain types of materials, such as Y-zeolite, are well-suited as an organizational medium for construction of such assemblies and much progress has been made recently in our laboratory in the synthesis and photophysical characterization of these promising materials.

Reviews

Selected Publications


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