Assistant Professor
Department of Biomedical Sciences
Schroeder Complex 429G
414-288-4532
aaron.roseberry@marquette.edu
Education & Professional Experience:
B.A., Northwestern University
M.S., Colorado State University
Ph.D., Northwestern University
Post-doctoral fellow, The Rockefeller University
Post-doctoral fellow/Research Assistant Professor, The Vollum Institute, Oregon Health Sciences University
Scientist, The Coca-Cola Company
Research Interests:
Neurobiology of Feeding and Food Reward
Work in my lab centers on examining the neural regulation of food intake and body weight. Our primary research interest is the role that reward systems play in the regulation of food intake including the intake of palatable foods. It has been suggested that reward systems were designed to respond to natural rewards such as food, and recent research has demonstrated that leptin, ghrelin and other feeding-related hormones can act on dopamine neurons within the ventral tegmental area and substantia nigra pars compacta. In our studies we use primarily patch-clamp electrophysiology and molecular genetics approaches to examine the role that dopaminergic systems play in the regulation of food intake and body weight, with a focus on both how dopamine neurons regulate feeding and how food can act as a natural reward to affect dopamine activity.
Selected References:
1. Roseberry, A.G*., Painter, T., Mark, G.P. and Williams, J.T. (2007) Decreased Vesicular Somatodendritic Dopamine Stores in Leptin-Deficient Mice. J Neurosci 27, 7021-7027. (* corresponding author)
2. Pinto, S.*, Roseberry, A.G.*, Liu, H.*, Diano, S., Shanabrough, M., Cai, X., Friedman, J.M., and Horvath, T.L. (2004) Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin. Science 304, 110-115. (* equal authorship)
3. Roseberry, A.G., Liu, H., Jackson, A.C., Cai, X., and Friedman, J.M. (2004) Neuropeptide Y-Mediated Inhibition of Proopiomelanocortin Neurons in the Arcuate Nucleus Shows Enhanced Desensitization in ob/ob Mice. Neuron 41, 711-722.
4. Liu, H., Kishi, T., Roseberry, A.G., Cai, X., Lee, C.E., Montez, J.M., Friedman, J.M., and Elmquist, J.K. (2003) Transgenic Mice Expressing Green Fluorescent Protein Under the Control of the Melanocortin-4 Receptor Promoter. J Neurosci 23, 7143-7154.
