John R. Mantsch, Ph.D.
Associate Professor

Chair

Pharmacology

Office:

Schroeder Complex, 429D
Tel: (414) 288-2036; Fax: (414) 288-6564

john.mantsch@marquette.edu

Lab:

Schroeder Complex, SC415

Academic Experience:

B.S., Psychology, Allegheny College, Meadville, PA (1993)

Ph.D., Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport, LA (1999)

Post-doctoral Training, Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY (1999-2001)

Assistant Professor of Pharmacology, Department of Biomedical Sciences (2001-present)

Associate Professor of Pharmacology, Department of Biomedical Sciences (2008-present)

Director, College of Health Sciences Biomedical Sciences Summer Research Program

Member of Marquette University Integrative Neuroscience Research Center (INRC)

Member of the Marquette University Addiction Research Division

Research Interests:

My research program investigates the neurobiological basis for the link between stress and cocaine addiction. Stress promotes cocaine-seeking behavior in part by facilitating cocaine-induced neuroplasticity that is pathogenic for addiction. At the same time, cocaine use makes addicts more vulnerable to stress and therefore more susceptible to stressor-induced cocaine-seeking behavior. The goal of my research is to develop novel therapeutic approaches for the management of cocaine addiction aimed at minimizing the contribution of stress to the addiction process. Of particular interest is the role of interactions between the stressor-responsive hypothalamic-pituitary adrenal axis and the neuropeptide, corticotropin-releasing factor (CRF), in the relationship between stress and drug use.  Secondary areas of research include the examination of cellular and molecular mechanisms underlying cocaine addiction using transgenic mice and the development of new medications for the treatment of cocaine addiction.  My laboratory utilizes a wide range of molecular, neuropharmacological, and behavioral approaches to study cocaine addiction and is funded by the National Institute on Drug Abuse (NIDA).

Teaching:

BISC 435, Dental Pharmacology (Course Director)

BISC 420, Medical Pharmacology (Course Director)

BISC 120, Pharmacology

Selected Publications:

1. Mantsch JR, Baker DA, Francis DM, Katz ES, Hoks MA, Serge JP (2008) Stressor and corticotropin releasing factor induced reinstatement and active stress-related behavioral responses are augmented following long-access cocaine self-administration by rats.  Psychopharmacology 195: 591-603.
2. Mantsch JR, Baker DA, Serge JP, Hoks MA, Francis DM, Katz ES (2008) Surgical adrenalectomy with diurnal corticosterone replacement slows escalation and prevents the augmentation of cocaine-induced reinstatement in rats self-administering cocaine under long-access conditions. Neuropsychopharmacology 33:814-26.
3. Mantsch JR (2007).  Drug Use and Abuse.  In: Encyclopedia of Stress Volume 1, 2nd Edition, Editor: George Fink, pp. 866-870.  Academic Press, Oxford. 
4. Mantsch JR, Katz ES (2007) Elevation of glucocorticoids is necessary but not sufficient for the escalation of cocaine self-administration by chronic electric footshock stress in rats. Neuropsychopharmacology 32:367-76.
5. Mantsch JR, Taves S, Khan T, Katz ES, Sajan T, Tang LC, Cullinan WE, Ziegler DR (2007) Restraint-induced corticosterone secretion and hypothalamic CRH mRNA expression are augmented during acute withdrawal from chronic cocaine administration. Neurosci Lett 415:269-73.
6. Mantsch JR, Li SJ, Risinger R, Awad S, Katz E, Baker DA, Yang Z (2007) Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats.  Psychopharmacology 192:581-91.
7. Mantsch JR, Cullinan WE, Tang LC, Baker DA, Katz ES, Hoks MA, Ziegler DR (2007) Daily cocaine self-administration under long-access conditions augments restraint-induced increases in plasma corticosterone and impairs glucocorticoid receptor-mediated negative feedback in rats.  Brain Research 1167: 101-111.
8. Mantsch JR, Yuferov V, Mathieu-Kia A-M, Ho A, Kreek MJ (2004) Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology 175: 26-36.  
9. Mantsch JR, Yuferov V, Mathieu-Kia A-M, Ho A, Kreek MJ (2004). Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology 175: 26-36.
10. Mantsch JR, Yuferov V, Mathieu-Kia, A-M, Ho A, Kreek MJ (2003). Neuroendocrine alterations in a rat high-dose, extended-access self-administration model of escalating cocaine use. Psychoneuroendocrinology 28: 836-862.
11. Mantsch JR, Ho A, Schlussman SD, Kreek MJ (2001). Predictable individual differences in the initiation of cocaine self-administration by rats under extended access conditions are dose-dependent. Psychopharmacology 157: 31-39.
12. Mantsch JR, Schlussman SD, Ho A, Kreek MJ (2000). Effects of cocaine self-administration on plasma corticosterone and prolactin in rats. Journal of Pharmacology and Experimental Therapeutics 294: 239-247.
13. Mantsch JR, Goeders NE (1999). Ketoconazole blocks the stress-induced reinstatement of cocaine-seeking behavior in rats: Relationship to the discriminative stimulus effects of cocaine. Psychopharmacology 142: 399-407.
14. Mantsch JR, Saphier D, Goeders NE. (1998). Corticosterone facilitates the acquisition of intravenous cocaine self-administration in rats: Opposite effects of the Type II glucocorticoid receptor agonist, dexamethasone. Journal of Pharmacology and Experimental Therapeutics 287: 72-80.
15. Mantsch JR, Goeders NE (1998). Generalization of a restraint-induced discriminative stimulus to cocaine in rats. Psychopharmacology 135: 423-426.