John R. Mantsch, Ph.D.
Assistant Professor

Pharmacology

Office:

Schroeder Complex, SC320D
(414) 288-2036
E-mail

Lab:

Schroeder Complex, SC306

(414) 288-2037

Academic Experience:

B.S., Psychology, Allegheny College, Meadville, PA (1993)

Ph.D., Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport, LA (1999)

Post-doctoral Training, Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY (1999-2001)

Assistant Professor of Pharmacology, Department of Biomedical Sciences (2001-present)

Director, College of Health Sciences Biomedical Sciences Summer Research Program

Chair, College of Health Sciences Faculty Development Committee

Faculty Advisor, Biomedical Sciences Student Association (BMSA)

Center Scientist and Executive Board Member, Center for Addiction and Behavioral Health Research (CABHR)

Member of Marquette University Integrative Neuroscience Research Center (INRC)

Member of the Marquette University Addiction Research Division

Research Interests:

My research program investigates the neurobiological basis for the link between stress and cocaine addiction.  Stress promotes cocaine-seeking behavior in part by facilitating cocaine-induced neuroplasticity that is pathogenic for addiction.  At the same time, cocaine use makes addicts more vulnerable to stress and therefore more susceptible to stressor-induced cocaine-seeking behavior.  The goal of my research is to develop novel therapeutic approaches for the management of cocaine addiction aimed at minimizing the contribution of stress to the addiction process.  Of particular interest is the role of the stressor-responsive hypothalamic-pituitary adrenal axis in the relationship between stress and drug use. 

Secondary areas of research include the examination of cellular and molecular mechanisms of cocaine-induced neuroplasticity using transgenic mice and collaborative projects with the functional imaging research group at the Medical College of Wisconsin.

My laboratory utilizes a wide range of molecular, neuropharmacological, and behavioral approaches to study cocaine addiction.  In addition to my preclinical research projects, I have recently initiated a clinical research program in collaboration with Dr. Todd Campbell <link> in the Department of Counseling and Educational Psychology at Marquette aimed at examining stress responses in human cocaine addicts.  My research is funded by the National Institute on Drug Abuse (NIDA).

Teaching:

BISC 435, Pharmacology (Course Director) - visit Dr. Mantsch's teaching webpage.

BISC 120, Pharmacology - visit Dr. Baker's webpage

Selected Publications:

1. Mantsch JR, Goeders NE. 1998. Generalization of a restraint-induced discriminative stimulus to cocaine in rats. Psychopharmacology 135: 423-426.
2. Mantsch JR, Saphier D, Goeders NE. 1998. Corticosterone facilitates the acquisition of intravenous cocaine self-administration in rats: Opposite effects of the Type II glucocorticoid receptor agonist, dexamethasone. Journal of Pharmacology and Experimental Therapeutics 287: 72-80.
3. Mantsch JR, Goeders NE. 1999. Ketoconazole blocks the stress-induced reinstatement of cocaine-seeking behavior in rats: Relationship to the discriminative stimulus effects of cocaine. Psychopharmacology 142: 399-407.
4. Mantsch JR, Goeders NE. 1999 Ketoconazole does not block cocaine discrimination or the cocaine-induced reinstatement of cocaine-seeking behavior. Pharmacology Biochemistry and Behavior 64: 65-73.
5. Mantsch JR, Goeders NE. 2000 Effects of cocaine self-administration on plasma corticosterone in rats: Relationship to hippocampal Type II glucocorticoid receptors. Progress in Neuro-Psychopharmacology & Biological Psychiatry 24: 633-646.
6. Mantsch JR, Schlussman SD, Ho A, Kreek MJ. 2000. Effects of cocaine self-administration on plasma corticosterone and prolactin in rats. Journal of Pharmacology and Experimental Therapeutics 294: 239-247.
7. Mantsch JR, Ho A, Schlussman SD, Kreek MJ. 2001. Predictable individual differences in the initiation of cocaine self-administration by rats under extended access conditions are dose-dependent. Psychopharmacology 157: 31-39.
8. Zhang, Y, Mantsch JR, Schlussman SD, Ho A, Kreek MJ. 2002. Conditioned place preference after single doses or “binge” cocaine in C57BL/6J and 129/J mice. Pharmacology Biochemistry and Behavior 73: 655-662.
9. Mantsch JR, Yuferov V, Mathieu-Kia, A-M, Ho A, Kreek MJ. 2003. Neuroendocrine alterations in a rat high-dose, extended-access self-administration model of escalating cocaine use. Psychoneuroendocrinology 28: 836-862.
10. Mantsch JR, Yuferov V, Mathieu-Kia A-M, Ho A, Kreek MJ. 2004. Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology 175: 26-36.