Said H. Audi, Ph.D.

Associate Professor of Biomedical Engineering Marquette University Zablocki VA Medical Center Research Service 151 5000 W. National Ave. Milwaukee, WI 53295 Email: said.audi@marquette.edu

Research Interests:

• Pulmonary mass transfer
• Tracer kinetics
• Mathematical modeling of physiological systems
• Pulmonary hemodynamics
• Functional imaging

Professional Preparation

Appointments/Professional Experience

Relevant Publications (* indicates graduate student)

Audi, S.H., R.D Bongard, Y Okamoto, M.P. Merker, D.L. Roerig, and C.A. Dawson. Pulmonary Reduction of an Intravascular Redox Polymer. American Journal of Physiology (Lung Cellular and Molecular Physiology) 280:L1290-L1299, 2001.

Audi, S.H., C.A. Dawson, S.B. Ahlf, and D.L. Roerig. Oxygen dependency of monoamine oxidase activity in the intact lung. American Journal of Physiology (Lung Cellular and  Molecular Physiology) 281:L969-L981, 2001.

Audi, S.H., C.A. Dawson, S.B. Ahlf, and D.L. Roerig. Lung tissue mitochondrial benzodiazepine receptors increase in a model of pulmonary inflammation. Lung  180:241-250, 2002.

Audi, S.H., H. Zhao, R.D. Bongard, N. Hogg, N.M. Kettenhofen, B. Kalyanaraman, C.A. Dawson, and M.P. Marilyn. Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0. Free Radical Biology and Medicine 34 (7):892-907, 2003.

Rhodes, S. S., K.M. Ropella, S.H. Audi, A.K. Camara, L.G. Kevin, P.S. Pagel, and D.F. Stowe. Cross-Bridge Kinetics Modeled from Myoplasmic [Ca2+] and LV Pressure at 17°C, and after 37°C and 17°C Ischemia. American Journal of Physiology  (Heart Circ Physiol.) 284(4):H1217-H229, 2003.

Effros, R.M., L. Olson, W. Lin, S. Audi, G. Hogan, R. Shaker, K. Hoagland, and B. Foss. Resistance of the Pulmonary Endothelium to Movement of Buffer Ions. American Journal of Physiology (cell. Mol. Physiol.) 285:L476-L483, 2003.

Audi, S.H., R.D. Bongard, C.A. Dawson, D. Siegel, D.L. Roerig, and M.P. Merker. Duroquinone Reduction During Passage Through the Pulmonary Circulation. American Journal of Physiology  (Lung Cellular Molecular Physiology) 285(5): L1116-L1131, 2003.

Merker, M.P., G.S. Krenz, R.D. Bongard, H. Zhao, *V. Fernandes, N.J. Kettenhofen, D. Siegel, B. Kalyanaraman, N. Hogg, and S.H. Audi. Impact of pulmonary arterial endothelial cells on duroquinone redox status.  Free Radical Biology and Medicine 37(1):86-103, 2004.

John LaDisa, Jr., L.E. Olson, I. Guler, D.A. Hettrick, S.H. Audi, K.M. Ropella, J.R. Kersten, D.C. Warltier, and P.S. Pagel. Design Properties And Deployment Ratio Influence Indices Of Wall Shear Stress: A 3d Computational Fluid Dynamics Investigation Within A Normal Artery. Journal of Applied Physiology  97(1):424-430, 2004.

David L. Roerig, Said H. Audi, Susan B. Ahlf. Kinetic characterization of P-glycoprotein mediated efflux of rhodamine 6G in the intact rabbit lung. Drug Metabolism and Disposition 32(9):953-958, 2004.

Audi, S.H., R.D. Bongard, D.L. Roerig, D.A. Rickaby, G.S. Krenz, and M.P. Merker. Effect of chronic exposure to hyperoxia on duroquinone reduction in adult rat lungs. American Journal of Physiology  (Lung Cellular Molecular Physiology) 289(5): L788-L797, 2005.

Merker, M.P., S.H. Audi, R.D. Bongard, B.J. Lindemer, and G.S. Krenz. Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia induced NAD(P)H: quinone oxidoreductase 1 (NQO1) American Journal of Physiology  (Lung Cellular Molecular Physiology) 290(3):L607-L619, 2006.

Clough, AV, S.H. Audi, R.C. Molthen, and G.S. Krenz. Lung Circulation Modeling: Status and Prospect. Proceedings of IEEE 94 (4):753-769, 2006.

Rhodes, SS, AK Camara, KM Ropella, S.H. Audi, ML Riess, PS Pagel, and DF Stowe. Iscehmia reperfusion dysfunction changes model-estimated kinetics of myofilament interactions due to inotropic drugs in isolated hearts. BioMedical Engineering OnLine 2; 5:16, 2006.

Merker, M.P., S.H. Audi, B.J. Lindemer, G.S. Krenz, and R.D. Bongard. Role Of Mitochondrial Electron Transport Complex I In Coenzyme Q1 Reduction By Intact Pulmonary Arterial Endothelial Cells And The Effect Of Hyperoxia. American Journal of Physiology  (Lung Cellular Molecular Physiology) (in press).

Audi, S.H., *M. Poellmann, X. Zhu, and M. Zhao. Quantitative Analysis Of 99mTc-C2A-GST Distribution In The Area-At-Risk After Myocardial Ischemia And Reperfusion Using A Compartmental Model.  Nuclear Medicine and Biology  (in press).

Current Research Funding