John F. LaDisa, Jr., Ph.D.

Assistant Professor of Biomedical Engineering Marquette University Olin Engineering Center, Room 401 1515 West Wisconsin Avenue Milwaukee, WI 53233 Email: john.ladisa@marquette.edu Website: http://www.eng.mu.edu/~ladisaj/

Research Interests:

1. Quantify hemodynamic and physiologic alterations as indices of morbidity after surgical or transcatheter treatments for congenital diseases
2. Characterize interactions between altered hemodynamics associated with stent implantation, diabetes or atherogenesis and the development of neointimal hyperplasia
3. Design and implement novel engineering devices and interventions for the treatment of cardiovascular diseases, particularly in children
4. Develop tools for predictive surgical or interventional treatment planning

Professional Preparation

Research/Professional Experience

Honors

Patents

• Proprietary medical device patent - #60/659,XXX (pending)
• Method and apparatus for treating seizure disorders by stimulating the thalamic reticular nucleus - #60/659,233 (pending)
• Proprietary stent patent - #60/659,XXX (pending)
  
  

Relevant Publications (* indicates graduate student)

BOOK CHAPTERS

John F. LaDisa, Jr., Charles A. Taylor, Jeffrey A. Feinstein. Endovascular treatment strategies for coarctation of the aorta. In: Current Treatment of Thoracic Aortic Diseases. 2006. Editor: Herve Rousseau, Springer, pp. 363-374.

JOURNAL ARTICLES

1. Richard Rys, John F. LaDisa, Jr., John P. Tessmer, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. An automated coronary artery occlusion device for stimulating collateral development in vivo. Journal of Pharmacological and Toxicological Methods. 2002; 48:111-18.

2. Katsuya Tanaka, Dorothee Weihrauch, Franz Kehl, Lynda M. Ludwig, John F. LaDisa Jr., Judy R. Kersten, Paul S. Pagel, and David C. Warltier. Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species. Anesthesiology. 2002 Dec; 97(6):1485-1490.

3. John F. LaDisa Jr., Douglas A. Hettrick, Lars E. Olson, Ismail Guler, Eric R. Gross, Tobias T. Kress, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Stent implantation alters coronary artery hemodynamics and wall shear stress during maximal vasodilation. J Appl Physiol. 2002 Dec; 93(6):1939-1946.

4. Franz Kehl, John G. Krolikowski, John F. LaDisa Jr., Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Adenosine type 1 (A(1)) receptors mediate protection against myocardial infarction produced by chronic, intermittent ingestion of ethanol in dogs. Int J Cardiol. 2003 Apr; 88(2-3):175-82.

5. John F. LaDisa, Jr., Eric R. Gross, Dorothee Weihrauch, Douglas A. Hettrick, Lars E. Olson, Tobias Kress, Paul S. Pagel, David C. Warltier, and Judy R. Kersten. Reactive oxygen species modulate alterations in coronary wall shear stress and endothelial function during hyperglycemia. Am J Physiol Heart Circ Physiol. 2003 May; 284(5):H1552-H1559.

6. John F. LaDisa Jr., Ismail Guler, Lars E. Olson, Douglas A. Hettrick, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Three-dimensional computational fluid dynamics modeling of alterations in coronary artery wall shear stress produced by stent implantation. Annals of Biomedical Engineering. 2003 Aug; 31(8):972-980.

7. Franz Kehl, John F. LaDisa Jr., Douglas A. Hettrick, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Influence of isoflurane on left atrial function in dogs with pacing-induced cardiomyopathy: Evaluation with pressure-volume relationships. J of Cardiothoracic and Vascular Anesthesia. 2003 Dec; 17(6):709-14.

8. Lynda M. Ludwig, Judy R. Kersten, Katsuya Tanaka, Weidong Gu, John F. LaDisa, Jr., David C. Warltier, and Paul S. Pagel. Mechanisms of volatile anesthetic-induced myocardial protection. Current Topics in Pharmacology. 2003; 7(2): 195-207.

9. John F. LaDisa, Jr., Lars E. Olson, Ismail Guler, Douglas A. Hettrick, Said H. Audi, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Stent design properties and deployment ratio influence indices of wall shear stress: a 3D computational fluid dynamics investigation within a normal artery. J Appl Physiol. 2004 July; 97(1):424-430.

10. John F. LaDisa Jr., John G. Krolikowski, Paul S. Pagel, David C. Warltier, and Judy R. Kersten. Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2): H601-H607.

11. John F. LaDisa, Jr., Heidi T. Meier, Lars E. Olson, Judy R. Kersten, David C. Warltier and Paul S. Pagel. Antegrade iliac artery stent implantation for the temporal and spatial examination of stent-induced neointimal hyperplasia and alterations in regional fluid dynamics. Journal of Pharmacological and Toxicological Methods. 2005 Mar-Apr; 51(2):115-21.

12. John F. LaDisa, Jr., Lars E. Olson, Ismail Guler, Douglas A. Hettrick, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Circumferential vascular deformation after stent implantation alters wall shear stress evaluated using time-dependent 3D computational fluid dynamics models. J Appl Physiol. 2005; 98(3):947-57.

13. John F. LaDisa, Jr., Lars E. Olson, Robert C. Molthen, Douglas A. Hettrick, Michael D. Hardel, Phillip F. Pratt, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Alterations in wall shear stress predict sites of neointimal hyperplasia after stent implantation in rabbit iliac arteries. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2465-75.

14. John F. LaDisa, Jr., Lars. E. Olson, Kristina M. Ropella, Robert C. Molthen, Steven T. Haworth, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Microfocal x-ray computed tomography post-processing operations for optimizing reconstruction volumes of stented arteries during 3D computational fluid dynamics modeling. Computer Methods and Programs in Biomedicine. 2005 Aug; 79(2):121-34.

15. John F. LaDisa, Jr., Lars E. Olson, Douglas A. Hettrick, David C. Warltier, Judy R. Kersten, and Paul S. Pagel. Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening. Biomed Eng Online. 2005 Oct 26; 4(1):59.

16. John F. LaDisa, Jr., Lars E. Olson, Douglas A. Hettrick, David C. Warltier, Judy R. Kersten, and Paul S. Pagel. Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling. Biomed Eng Online. 2006 June 16; 5:40.

17. John F. LaDisa, Jr., C. Alberto Figueroa, Irene E. Vignon-Clementel, Frandics P. Chan, Charles A. Taylor, and Jeffrey A. Feinstein. Patient-specific modeling of altered hemodynamics and arterial deformation induced by aortic coarctation: potential sources of long-term morbidity (manuscript in preparation).

Current Research Funding