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Dr. Chieu D. Tran

Dr. Chieu D. Tran
Dr. Chieu D. TranMarquette University

Wehr Chemistry Building, 470

MilwaukeeWI53201United States of America
(414) 288-5428

Professor Emeritus

Chemistry

Education

Ph.D., Texas A&M University

B.S., Kumamoto University, Japan

Research Interests

Our research involves the development and applications of novel instruments and methods for fundamental studies in analytical chemistry and material science. The overall objective of these studies is to gain insight into complex chemical and biochemical systems and processes as well as to develop novel biomaterials and high performance chemical and biosensors. We are approaching this goal from many different directions. Selected ongoing projects are:

  • Development of an acousto-optic tunable filter (AOTF) as the "New Generation Monochromator" that has fast scanning speed, high throughput and wide spectral tuning range, and use it to develop novel instruments which otherwise are not possible.
  • Synergistically combining spectroscopy and imaging to develop a novel near-infrared multispectral imaging (NIR-MSI) instrument and microscope which can rapidly (milliseconds) records tens of thousands of spectra at tens of thousands of different positions within a sample with spatial resolution of ~10 microns and ~1 micron, respectively.
  • Investigate biomedical application of the NIR-MSI instrument and microscope including their use for noninvasive detection of cancer.
  • Explore the use of the NIR-MSI microscope to visualize single nano- and microparticles in order to characterize them and to monitor changes induced by either light, heat or chemicals. 
  • Extend applications of the mutispectral imaging instrument to material science, namely, using the imaging instruments to determine chemical inhomogeneity, and correlation between the inhomogeneity and physical properties of a variety of materials including biopolymers, sol-gels and nanocomposite materials,
  • Synthesis and characterization, of novel room temperature ionic liquids, and exploit their unique properties to develop novel methods which otherwise are not possible, e.g., novel chiral selector for capillary electrophoresis (CE), novel stationary phases (SPs) for GC and HPLC.
  • Development of green and recyclable method to synthesize high performance, biocompatible and biodegradable supramolecular composite materials from biopolymers (e.g., cellulose, chitosan, cyclodextrins) and exploit their biomedical, bioanalytical and analytical applications including removal of pollutants, toxins and bacterias.

Professional Experience

Professor Tran received his B.S. degree from Kumamoto University in Japan and his Ph. D. from Texas A & M University. He joined Brookhaven National Laboratory as a Staff Scientist in 1982 after spending two years doing post doctoral research at the Royal Institution of Great Britain. He has been on the faculty at Marquette University since 1986.

Editorial Advisory Boards

  • Analytical Letters
  • Applied Spectroscopy Reviews
  • Microchemical Journal
  • Talanta

Click to expand selected publications

  1. Chieu D. Tran, “Acousto-Optic Devices: Optical Elements for Spectroscopy”, Anal. Chem. 64, 971A-981A (1992).
  2. Chieu D. Tran, “Principles and Analytical Applications of Acousto-Optic Tunable Filters, an Overview”, Talanta, 45, 237-248 (1997).
  3. Chieu D. Tran, “Acousto-optic Tunable Filter: A New Generation Monochromator and More”,  Anal. Let. 33, 1711 - 1732 (2000).
  4. Chieu D. Tran and Ricardo J. Furlan, "Acousto-Optic Tunable Filter as a Polychromator and Its Application in Multidimensional Fluorescence Spectrometry", Anal. Chem., 64, 2775-2782 (1992).
  5. Chieu D. Tran and Ricarado J. Furlan, "Spectrofluorimeter based on Acousto-Optic Tunable Filters For Rapid Scanning and Multicomponent Sample Analyses", Anal. Chem., 65, 1675-1681 (1993).
  6. M. J. Politi, Chieu D. Tran and Guan-Hong Gao, "Near Infrared Spectroscopic Investigation of Inclusion Complexes between Cyclodextrins and Aromatic Compounds", J. Phys. Chem., 99, 14127-14141 (1995).
  7. Mauricio S. Baptista, Chieu D. Tran and Guan-Hong Gao, "Near Infrared Detection of Flow Injection Analysis by Acousto-Optic Tunable Filter Based Spectrophotometry", Anal. Chem., 68, 971-976 (1996).
  8. Chieu D. Tran and Guan-Hong Gao, "Characterization of an Erbium Doped Fiber Amplifier as a Light Source and Development of a Near-Infrared Spectrophotometer based on the EDFA and an Acousto-Optic Tunable Filter", Anal. Chem., 68, 2264-2269 (1996).
  9. Chieu D. Tran and Guan-Hong Gao, "Determination of Monomethylhydrazine with a Novel, High Throughput, All Fiber Near Infrared Spectrometer Based on Integrated Acousto-Optic Tunable Filter and Erbium Doped Fiber Amplifier", Anal. Chem., 69, 1461-1464 (1997).
  10. Mauricio S. Baptista and Chieu D. Tran, "Near Infrared Thermal Lens Spectrometer based on Erbium Doped Fiber Amplifier and Acousto-Optic Tunable Filter and its Application in the Determination of Nucleotides", Appl. Optics, 36 (27), 7059-7065 (1997).
  11. Mauricio S. Baptista and Chieu D. Tran, "Electrical Conductivity, Near Infrared Absorption and Thermal Lens Spectroscopic Studies of Percolation of Microemulsions", J. Phys. Chem. B., 101, 4209-4217 (1997).
  12. Troy A. Alexander, Guan-Hong Gao and Chieu D. Tran, "Development of a Novel Fluorimeter based on Superluminescent Light Emitting Diodes and an Acousto-Optic Tunable Filter and its Application in the Determination of Chlorophyll a and b", Appl. Spectrosc., 51, 1603-1606 (1997).
  13. Chieu D. Tran, Mauricio Baptista and Takuya Tomooka, "Determination of Binding Constants by Flow Injection Gradient Technique", Langmuir, 14, 6886-6892 (1998).
  14. Chieu D. Tran and Silvia de Paoli Lacerda, “Determination of Binding Constants of Cyclodextrins in Room Temperature Ionic Liquids by Near-Infrared Spectrometry”, Anal. Chem., 74, 5337-5341 (2002).
  15. Chieu D. Tran, Yan Cui and Sergey Smirnov, "Simultaneous Multispectral Imaging in the Visible and Near Infrared Region: Applications in Document Authentication and Determination of Chemical Inhomogeneity of Copolymers", Anal. Chem., 70, 4701-4708 (1998).
  16. Mark Fischer and Chieu D. Tran, "Evidence for Kinetic Inhomogeneity in the Curing of Epoxy using the Near-infrared Multispectral Imaging Technique", Anal. Chem., 71, 953-959 (1999).
  17. Chieu D. Tran and G. C. Huang, "Characterization of the Collinear Beam Acousto-optic Tunable Filter (CB-AOTF) and its Comparison with the Noncollinear AOTF and the Integrated AOTF", Opt. Eng., 38, 1143-1148 (1999).
  18. Chieu D. Tran, "Acousto-Optic Tunable Filter: A New Generation Monochromator and More", Anal. Lett. 33, 1711-1732 (2000).
  19. Chieu D. Tran, "Visualizing Chemical Composition and Reaction Kinetics by Near-infrared Multispectral Imaging Technique", J. Near-Infrared Spectrosc., 8, 87-99 (2000).
  20. Chieu D. Tran and Xiangrong Kong, "Determination of Identity and Sequences of Tri- and Tetrapeptides by Near-Infrared Spectrometry", Anal. Biochem., 286, 67-74 (2000).
  21. Oleg Khait, Sergey Smirnov and Chieu D. Tran, "Time Resolved Multispectral Imaging Spectrometer", Appl. Spectrosc., 54, 1734-1742 (2000).
  22. Marc Fischer and Chieu D. Tran, "Thermal Lens Induces Anomalous Solvent's Effect in Two Photon Excited Fluorescence with a CW Laser Excitation", Appl. Opt., 20, 6257-6262 (2000).
  23. Troy Alexander and Chieu D. Tran, "Near-infrared Multispectral Imaging Technique for Visualizing Sequences of Di- and Tripeptides Synthesized by Solid Phase Combinatorial Method", Appl. Spectrosc., 55, 939-945 (2001).
  24. Chieu D. Tran and Mario Politi, “Visualizing Chemical Composition and Reaction Kinetics of Sol-Gel by Near-Infrared Multispectral Imaging Technique”, Anal. Chem., 74, 1604 - 1610 (2002).
  25. Marc Fischer and Chieu D. Tran, "Investigation of Solid Phase Peptide Synthesis by the Near Infrared Multispectral Imaging Technique: A Detection Method for Combinatorial Chemistry", Anal. Chem., 71, 2255-2262 (1999).
  26. Oleg Khait, Sergey Smirnov and Chieu D. Tran, "Multispectral Imaging Microscope with Millisecond Time Resolution", Anal. Chem., 73, 732-739 (2001).
  27. Troy Alexander and Chieu D. Tran, "Near Infrared Spectrometric Determination of Di- and Tripeptides Synthesized by Combinatorial Solid Phase Method", Anal. Chem., 73, 1062 - 1067 (2001).
  28. Troy Alexander and Chieu D. Tran, "Simultaneous Measurement of One- and Two-Photon Excited Fluorescence from a Single Sample: A Detection Method for Oligonucleotides", Appl. Opt., 41, 2285-2291 (2002).
  29. Chieu D. Tran and Mario Politi, "Visualizing Chemical Composition and Reaction Kinetics of Sol-Gel by Near-Infrared Multispectral Imaging Technique", Anal. Chem., 74, 1604 - 1610 (2002).
  30. Chieu D. Tran and Silvia de Paoli Lacerda, "Determination of Binding Constants of Cyclodextrins in Room Temperature Ionic Liquids by Near-Infrared Spectrometry", Anal. Chem., 74, 5337-5341 (2002).
  31. Chieu D. Tran and Jianxia Kang, “Chiral Separation of Amino Acids by Capillary Electrophoresis with 3-[(3-Cholamidopropyl)-dimethylammonio]-1-propane sulfonate (CHAPS) as Chiral Selector", Chromatographia, 57, 81 - 86 (2003).
  32. Chieu D. Tran, Silvia de Paoli Lacerda and Daniel Oliveira, "Absorption of Water by Room-Temperature Ionic Liquids: Affect of Anions on Concentration and States of Water", Appl. Spectrosc., 57, 152-157 (2003).
  33. Chieu D. Tran, "Infrared Multispectral Imaging: Principles and Instrumentation", Appl. Spectrosc. Rev., 38, 133-153 (2003).
  34. Andrea Mele, Chieu D. Tran and S. H. D. Paoli Lacerda, "The Structure of a Room Temperature Ionic Liquid with and without trace amounts of Water: The Role of C-H...O and C-H....F Interactions in 1-n-Butyl-3-Methylimidazolium Tetrafluoroborate", Angewandte Chem., 42, 4364 - 4366 (2003).
  35. Chieu D. Tran, Victor I Grishko and Daniel Oliveira, "Determination of Enantiomeric Compositions of Amino Acids by Near-Infrared Spectrometry through Complexation with Carbohydrate", Anal. Chem., 75, 6455 - 6462 (2003).
  36. Chieu D. Tran, Daniel Oliveira and Victor Grishko, “Determination of Enantiomeric Compositions of Pharmaceutical Products by Near-infrared Spectrometry”, Anal. Biochem., 325, 206-214 (2004).
  37. Chieu D. Tran, Dora Ilieva and Santhosh Challa “Investigation of Distribution and Conformation of Bovine Serum Albumin Entrapped in Sol-Gel by Near-Infrared Multispectral Imaging Technique”, J. Sol-Gel Sci. Tech., 32, 207-217 (2004).
  38. Chieu D. Tran and Victor Grishko, “Determination of Water Contents in Leaves by Near-infrared Multispectral Imaging Technique”, Microchem. J., 76, 91-94 (2004).
  39. Chieu D. Tran, Victor I. Grishko and Santhosh Challa “Near-infrared Spectrophotometric Determination of Compositions of Fullerene Samples”, Spectrochimica Acta A, 62, 38 – 41 (2005).
  40. Chieu D. Tran, "Principles, Instrumentation and Applications of Infrared Multispectral Imaging, An Overview", Anal. Lett., 38, 735-752 (2005).
  41. Chieu D. Tran and Shaofang Yu, "Spectroscopic and Electrophoretic Investigation of Chiral Interactions: Mechanism and Applications", J. Phys. Chem. B., 109, 12627-12636 (2005). PDF
  42. Chieu D. Tran, Santhosh Challa and Mladen Franko, "Ionic Liquids as an Attractive Alternative Solvent for Thermal Lens Measurements", Anal. Chem., 77, 7442-7447 (2005).
  43. Chieu D. Tran and Shaofang Yu, “Near-Infrared Spectroscopic Method for the Sensitive and Direct Determination of Aggregation of Surfactants in Various MediaJ.Coll. Interface Sci., 283, 613 - 618 (2005).
  44. Chieu D. Tran, Daniel Oliveira and Shaofang Yu, "New Chiral Ionic Liquid that Functions as Both Solvent and Chiral Selector for the Determination of Enantiomeric Compositions of Pharmaceutical Products", Anal. Chem., 78, 1349-1356 (2006).
  45. Chieu D. Tran, “Subnanogram Detection of Dyes on Filter Paper by Surface-Enhanced Raman Scattering Spectrometry”, Anal. Chem. 56, 824-826 (1984).
  46.  Chieu D. Tran, “In situ Identification of Paper Chromatogram spots by Surface-Enhanced Raman Scattering”, J. Chromatogr. 292, 432-438 (1984).
  47.  Clifford Frez, Gerald Diebold, Chieu D. Tran and Shaofang Yu, “Determination of Thermal Physical Properties of Room Temperature Ionic Liquids by Transient Grating Technique”, J. Chem. Eng. Data., 54, 1250-1255 (2006).
  48.  Chieu D. Tran and Daniel Oliveira, “Fluorescence Determination of Enantiomeric Composition of Pharmaceuticals vis Use of Ionic Liquid that Serves as Both Solvent and Chiral Selector”, Anal. Biochem., 356, 51-58 (2006).
  49. Chieu D. Tran, “Ionic Liquids for and by Analytical Chemistry”, Anal. Lett. 40, 2447-2464 (2007).
  50. Chieu D. Tran and Santhosh Challa, "Fullerenes Impregnated Ionic Liquid Stationary Phase for Gas Chromatography", Analyst, 133, 455-464 (2008).
  51. Shaofang Yu, Sergey Lindeman and Chieu D. Tran, "Novel Chiral Ionic Liquids: Synthesis, Properties and Applications", J. Org. Chem. 73, 2576-2591 (2008).
  52. Chieu D. Tran and Irena Mejac, “Chiral Ionic Liquids for Enantioseparation of Pharmaceutical Products by Capillary Electrophoresis”, J. Chromatogr. A, 1204, 204-209 (2008).
  53. Chieu D. Tran, Victor I Grishko and Santhosh Challa, “Molecular State and Distribution of Fullerenes Encapsulated in Sol-Gel by Multispectral Imaging Technique”, J. Phys. Chem.B , 112, 112, 14548-14559 (2008).
  54. Chieu D. Tran, “Spectroscopy for Ionic Liquids; Ionic Liquids for Spectroscopy” in “Green Chemistry Reactions”, Pietro Tundo  and Vittorio Esposito Eds., Springer, Netherlands, pp. 79-104 (2008).
  55. Chieu D. Tran, Irena Mejac, Julius Rebek and Richard J. Hooley, "Gas Chromatographic Separation of Isotopic Molecules using a Novel Cavitand- Impregnated Ionic Liquid Stationary Phase", Anal. Chem. 81, 1244-1254 (2009).
  56. Irena Mejac, William W. Bryan, T. Randall Lee and Chieu D. Tran, “Visualizing the Size, Morphology, and Localized Surface Plasmon Resonance of Individual Nanoshells by Near-infrared Multispectral Imaging Microscopy”, Anal. Chem., 81, 6687-6694 (2009).
  57. Simon Duri, Robert C. Molthen and Chieu D. Tran, “Discriminating Pulmonary Hypertension Caused by Monocrotaline Toxicity from Chronic Hypoxia by Near-Infrared Spectroscopy and Multivariate Methods of Analysis”, Anal. Biochem., 390,155-164 (2009).
  58. Ales Boskin, Chieu D. Tran and Mladen Franko, “Oxidation of Organophosphorous Pesticides with Chloroperoxidase Enzyme in the Presence of an Ionic Liquid as Co-Solvent”, Environ. Chem. Let., 7, 267-230 (2009).
  59. Simon Duri, Stephen Majoni, Jeanne M. Hossenlopp and Chieu D. Tran, “Determination of Chemical Homogeneity of Fire Retardant Polymeric Nanocomposite Materials by Near-infrared Multispectral Imaging Microscopy”, Anal. Lett.,43, 1780-1789 (2010).
  60. Chieu D. Tran, “Development of a Universal Method based on Ionic Liquids for Determination of Enantiomeric Compositions of Pharmaceutical Products”, in “Ionic Liquids Applications:  Pharmaceutical, Therapeutics and Biotechnology”, Sanjay Maholtra Eds., ACS Symposium Series, Volume 1038, Chapter 4, 2010pp 35-54, American Chemical Society Publishing.
  61. Irena Mejac, Hye-Hun Park, T. Randall Lee and Chieu D. Tran, “Visualizing the Lower Critical Solution Temperature of Individual Hydrogels by Near-infrared Multispectral Imaging Microscopy”, Anal. Chem., 82, 1698-1704 (2010).
  62. Irena Mejac and Chieu D. Tran, “Visualizing the Effect of Gold Nanocages on Absorption, Imaging and Lower Critical Solution Temperature Phase Transition of Individual Poly(NiPAM)-based Hydrogel Particles by Near Infrared Multispectral Imaging Microscopy”, Anal. Chem., 83, 3520-3527 (2011).
  63. Mladen Franko and Chieu D. Tran, “Thermal Lens Spectroscopy” in Encyclopedia of Analytical Chemistry, Supplementary Volumes S1-S3, eds R.A. Meyers, Chichester, UK:  John Wiley & Sons, Ltd., pp 1249-1279 (2011).
  64. Chieu D. Tran, D.Oliveira, V. Grishko, “Determination of Enantiomeric Compositions of Pharmaceutical Products by Near-infrared Spectrometry”, Anal. Biochem., 325, 206-214 (2004).
  65. Simon Duri, Bilal El-Zahab and Chieu D. Tran, “Polycaccharide Ecocomposite Materials. Characterization and Application for Removal of Pollutants and Bacteria”, ECS Transactions 50, 573-594 (2012).
  66. Chieu D. Tran, Simon Duri and April L. Harkins, “Recyclable Synthesis, Characterization and Antimicrobial Activity of Chitosan-based Polysaccharide Composite Materials”, J. Biomed. Mat. Res. A , 101, 2248-2257 (2013).
  67. Chieu D. Tran, Simon Duri, Ambra Delneri and Mladen Franko, “Chitosan-Cellulose Composite Materials” Preparation, Characterization and Application for Removal of Microcystin”, J. Hazad. Mater. 252-253, 355-366 (2013).
  68. Simon Duri and Chieu D. Tran, “Supramolecular Composite Materials from Cellulose, Chitosan and Cyclodextrin: Facile Preparation and their Selective Includion Complex Formation with Endocrine Disruptors”, Langmuir, 29, 5037-5049 (2013).
  69. Tamutsiwa M. Mututuvari, April L. Harkins and Chieu D. TranFacile Synthesis, Characterization and Antimicrobial Activity of Cellulose-Chitosan-Hydroxy Apatite Composite Material, A Potential Material for Bone Tissue Engineering”, J. Biomed. Mat. Res. A , 101, 3266-3277 (2013).
  70. Tamutsiwa M. Mututuvari and Chieu D. Tran, "Synergistic Adsorption of Heavy Metal Ions and Organic Pollutants by Polysaccharide Supramolecular Composite Materials from Cellulose, Chitosan and Crown Ether”, J. Hazard. Mater., 264, 449-459 (2014).
  71. April L. Harkins, Simon Duri, Luther C. Kloth and Chieu D. Tran, “Chitosan-Cellulose Composite for Wound Dressing Material. Part 2. Antimicrobial Activity, Blood Absorption Ability and Biocompatibility”, J. Biomed. Mat. Res. B, 102, 1199-1206 (2014).
  72. Simon Duri and Chieu D. Tran, "Enantiomeric Selective Adsorption of Amino Acid by Polysaccharide Composite Materials", Langmuir, 30(2), 642-650 (2014).
  73. Chieu D. Tran and Tamutsiwa Mututuvari, “Cellulose, Chitosan and Keratin Composite Materials. Controlled Drug Release”, Langmuir, 31, 1516-1526 (2015).
  74. Meghann Rosewald, Fang Yao Stephen Hou, Tamutsiwa Mututuvari, April L. Harkins and Chieu D. Tran,Cellulose-Chitosan-Keratin Composite Materials: Synthesis and Immunological and Antibacterial Properties”, ECS Transactions,64(4), 499-505 (2014).
  75. Chieu D. Tran and Tamutsiwa Mututuvari, “Cellulose, Chitosan and Keratin Composite Materials. Facile and Recyclable Synthesis, Conformation and PropertiesACS Sustainable Chem. Eng., 4(3), 1850-1861 (2016).
  76. Chieu D. Tran, Franja Prosenc, Mladen Franko and Gerald Benzi, “Green Composites from Cellulose, Wool, Hair and Chicken Feather. Synthesis, Structure and Antimicrobial Property”, Carb. Pol., 151, 1260-1276 (2016).
  77. Chieu D. Tran, Franja Prosenc, Mladen Franko and Gerald Benzi, “One-Pot Synthesis of Biocompatible Silver Nanoparticle Composites from Cellulose and Keratin: Characterization and Antimicrobial Activity”, ACS Appl. Mat. Interf., 8(50), 34791-34801 (2016).
  78. Simon Duri, April Harkins, Anna Frazier and Chieu D. Tran, “Composites Containing Fullerenes and Polysaccharides: Green and Facile Synthesis, Biocompatibility and Antimicrobial Activity”, ACS Sustainable Chem. Eng., 5, 5408-5417 (2017).
  79. Chieu D. Tran and Franja Prosenc, "Facile Synthesis, Structure, Biocompatibility and Antimicrobial Property of Gold Nanoparticle Composites from Cellulose and Keratin”, J. Coll. Interface. Sci.510, 237-245 (2018). p148
  80. Chieu D. Tran, James Makuvaza, Erik Munson and Brian Bennett, “Biocompatible Copper Oxide Nanoparticle Composites from Cellulose and Chitosan: Facile Synthesis, Unique Structure and Antimicrobial Activity”, ACS Appl. Mat. Interf. 9, 42503-42515 (2017). p150
  81. Inhibition of Biofilm Formation by Nanoparticle Composites.

The publications on this site are being made available to the academic community for use in teaching and research. All copyrights remain intact.

Honors and Awards

  • 2005 Lawrence G. Haggerty Award for Research Excellence
  • 2004 American Chemical Society (ACS), Milwaukee Section Award
  • 2003 Senior Invitation Fellowship given by the Japan Society for Promotion of Science (JSPS)
  • 2002 Sigma Xi Award for Distinguished Scientific Research Achievement
  • 1999 Gold Medal Award given by the New York Section of the Society for Applied Spectroscopy (SAS)
  • Shannon Award given by the National Institutes of Health (NIH)
  • 1992 Perkin-Elmer International Liquid Chromatography Technical Paper Award

Water Docs: Dr. Chieu Tran from doc|UWM on Vimeo.

Dr. Chieu Tran describes his lab's work in developing instruments that could be used to detect impurities in water. By combining various imaging methods, Dr. Tran's method can identify biological agents and mineral impurities in water, providing nearly instantaneous analysis.


Faculty & Staff


CONTACT

Department of Chemistry

Todd Wehr Chemistry, 101
1414 W Clybourn St.
Milwaukee, WI 53233
(414) 288-3515

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