Dr. Sandra Hunter's Research

Major areas of recent research

  • Sex and age differences in muscle fatigability and endurance performance
  • The impact of stress on neuromuscular function and muscle fatigue
  • The neural control of muscle fatigue and task failure with advanced age
  • Adaptations of neuromuscular aging: control of muscle force and motor unit variability

Funding

Principal investigator

2015-2020
National Institute of Aging R01 [R01 AG048262-01A1] ‘Fatigability of Limb Muscle in Older Adults: Protective Effects of Exercise.’ (C0-PI with Robert Fitts)

2015
Women’s Health Research Program at Medical College of Wisconsin. “Neuromuscular Function in Women postpartum”

2014-2016
National Institute of Aging R21 [R21 AG0457661] “Motor Function in Older Adults: the Importance of Apolipoprotein-E ?4 Inheritance.”

2014-2017
Way Klingler Fellowship at Marquette University “Neuromuscular Fatigue in People with Type 2 Diabetes”

2011-2014
National Institute of Aging R15 [R15AG039697] “Neuromuscular Fatigue: Sex and Age Differences

2011
Women’s and Gender Studies Collaborative Research Scholarship, Marquette University. “Gender Bias in Exercise Performance: Physiology or Participation”

2010-2012
CTSI Brain Imaging Pilot Grants (Medical College of Wisconsin) “Brain Activation and the Stress Response During Motor Performance in Older Adults

2008-2011
National Institute of Aging R15 [R15AG30730] “Neuromuscular Fatigue in Old Adults”

Co-investigator

2014-2017
National Institute of Health R15 [1R15NS084130] (PI: Hyngstrom A) “Title: Neural Mechanisms of Neuromuscular Fatigue Post Stroke”

2014-2016
National Institute of Health R21 [R21NS088818] (PI: Hyngstrom A) “Impaired Blood Flow and Neuromuscular Fatigue Post Stroke”

2013-2014
Clinical and Translational Science Institute of South East WI Small Pilot Grant (PI: Hyngstrom A) “Effects of Altered Perfusion on Neuromuscular Fatigue and Leg Function Post Stroke”

2011-2011
Clinical and Translational Science Institute of South East WI Small Pilot Grant (PI: Hyngstrom, A) “Mechanisms of Neuromuscular Fatigue Post Stroke”

2010-2011
American Heart Association Clinical Research Program (PI: Hyngstrom, A) “Leg Muscle Fatigue and Motor Function Post Stroke”

2009-2011
CTSI Doctoral Research Grant (Medical College of Wisconsin) “The Influence of Posttraumatic Stress Disorder on Motor Impairment in Veterans”

Honors and awards (from 2005)

2015
Appointed associate editor of Exercise and Sports Science Reviews

2014
Marquette University Excellence in Teaching Award

2014
Way Klingler Research in Science Fellowship, Marquette University

2014
Appointed associate editor of Medicine and Science in Sports and Exercise

2013
National Aeronautic and Space Administration (NASA) and the National Space Biomedical Research Institute Musculoskeletal Workgroup: Decadal Study workgroup that generated a report on “The Impact of Sex and Gender on Adaptation to Space.”

2013
College of Health Sciences Edward Carroll Teacher of the Year Award, Marquette University

2008
Dr. Judith Stitt Women’s Faculty Scholarship: Wisconsin Women’s Health Foundation

2007
Way Klingler Young Scholar Award, Marquette University

2005
Fellow of the American College of Sports Medicine (FACSM)

Professional publications

Refeered Journals (latest of 75)

Rozand V, Sundberg CW, Hunter SK, Smith AE. Age-related deficits in voluntary activation: a systematic review and meta-analysis.Medicine & Science in Sport & Exercise, Aug. 29, 2019, in press.

Senefeld J, D’Astice S, Harmer AR, and Hunter SK. Increased cardiovascular response to a 6-minute walk test in people with type 2 diabetes. Diabetes Spectrum. Aug. 16, 2019, in press.

Rozand V, Senefeld JW, Sundberg CW, Hunter SK. Differential effects of aging and physical activity on corticospinal excitability of upper and lower limb muscles. J. Neurophysiology. June 28th, 2019. https://doi.org/10.1152/jn.00077.2019, PMID:31091158

Senefeld JW, Hunter SK. Are masters athletic performances predictive of human aging in men and women? Mov Sport Sci/Sci Mot.July 12 2019. https://doi.org/10.1051/sm/2019018. Publication ahead of print.

 

Sundberg CW, Prost RW, Fitts RH, Hunter SK. Bioenergetic basis for the increased fatigability with ageing. J Physiol. 2019 Apr 24. doi: 10.1113/JP277803. [Epub ahead of print]. PMID: 31018011

Andsell P, Brownstein CG, Škarabot J, Hicks KM, Simoes D, Thomas K, Howatson G, Hunter SK, Goodall S.  Menstrual cycle associated modulations in neuromuscular function and fatigability of the knee extensors in eumenorrheic females. J Appl Physiol, published online Mar 7,2019. https://doi.org/10.1152/japplphysiol.01041.2018, PMID: 30844334

Deering RE, Pashibin T, Cruz M, Hunter SK, Hoeger Bement M. Fatiguing trunk flexor exercise decreases pain sensitivity in postpartum women.  Frontiers in Physiology, Mar 26;10:315. doi: 10.3389/fphys.2019.00315. eCollection 2019.  PMID: 30971949 https://www.ncbi.nlm.nih.gov/pubmed/30971949

Pereira HM, Schindler-Delap B, Keenan KG, Negro F, Farina D, Hyngstrom AS, Nielson KA, and Hunter SK. Oscillations in neural drive and age-related reductions in force steadiness with a cognitive challenge. J Appl Physiol, Apr 1;126(4):1056-1065, 2019. https://doi.org/10.1152/japplphysiol.00821.2018, PMID: 30817244

Senefeld J, Limberg JK, Lukaszewicz KM and Hunter SK. Exercise-induced hyperemia is associated with knee extensor fatigability in adults with Type 2 diabetes. J Appl Physiol. Mar 1;126(3):658-667, 2019. PMID: 30605399.

2018

Murphy SA, Negro F, Farina D, Onushko T, Durand M, Hunter SK, Schmit BD and Hyngstrom AS. Stroke increases ischemia-related decreases in motor unit discharge rates J Neurophysiol, 120: 3246 –3256, 2018. doi: 10.1152/jn.00923.2017. PMID: 30379629

Pereira HM, Schlinder-Delap B, Nielson KA, Hunter SK. Force steadiness during a cognitively challenging motor task is predicted by executive function in older adults. Frontiers in Physiology 9(1316), 2018.

Sundberg CW, Hunter SK, Trappe SW, Smith CS, Fitts R. Effects of elevated H+ and Pi on the contractile mechanics of skeletal muscle fibres from young and old men: implications for muscle fatigue in humans. J Physiol.  Sep;596(17):3993-4015, 2018.  PMID: 29806714 PMCID: PMC6117549.

Deering RE, Senefeld JW, Pashibin T, Neumann DA, Cruz M, Hunter SK. Fatigability of the lumbopelvic stabilizing muscles in women 8 and 26 weeks postpartum.  Journal of Women's Health Physical Therapy. Sep-Dec;42(3):128-138. 2018. PMID: 30740039. PMCID: PMC6366649.

Senefeld J, Magill SB, Harkins A, Harmer AR, Hunter SK. Mechanisms for the increased fatigability of the lower limb in people with Type 2 Diabetes. J Appl Physiol. Aug 1;125(2):553-566, 2018.  PMID: 29596017

Deering RE, Cruz M, Senefeld JW, Pashibin T, Eickmeyer S, Hunter SK. Impaired trunk flexor strength, fatigability and steadiness in postpartum women. Med Sci Sports Exer. Aug;50(8):1558-1569, 2018.  PMID: 29554014.

Sundberg CW, Kuplic A, Hassanlouei H, Hunter SK. Mechanisms for the age-related increase in fatigability of the knee extensors in old and very old adults. J Appl Physiol (1985). Jul 1;125(1):146-158, 2018. doi: 10.1152/japplphysiol.01141.2017 PMID: 29494293

Keenan, KG, Senefeld JW & Hunter SK.  Girls in the Boat: Sex Differences in Rowing Performance and Participation.  PLOS ONE.  Jan 19;13(1):e0191504. doi: 10.1371/journal.pone.0191504. eCollection 2018. PMID: 29352279.

Senefeld JW, Pereira HM, Elliott N, Yoon T and Hunter SK. Sex differences in mechanisms of recovery after isometric and dynamic fatiguing tasks.  Med Sci Sports Exerc. 50(5):1070-108, 2018 PMID: 29298217, PMCID: PMC5899026

2017

Rozand V, Senefeld JW, Hassanlouei H, Hunter SK. Voluntary activation and variability during maximal dynamic contractions with aging. Eur J Appl Physiol. Dec;117(12):2493-2507 2017.  PMID: 29058113.

        https://www.ncbi.nlm.nih.gov/pubmed/29058113

Andsell P, Thomas K, Howatson G, Hunter SK, Goodall S. Contraction intensity and sex differences in knee-extensor fatigability. J Electromyogr Kinesiol. Dec;37:68-74. 2017. doi: 10.1016/j.jelekin.2017.09.003.  PMID: 28963937

Hassanlouei H, Sundberg W, Smith E, Kuplic A, and Hunter SK.  Physical activity modulates corticospinal excitability of the lower limb in young and old adults. J Appl Physiol, Aug 1;123 (2):364-374.  DOI: 10.1152/japplphysiol.01078.20162017. PMCID: PMC5614787.

Hunter SK. Performance Fatigability: Mechanisms and Task Specificity. Cold Spring Harb Perspect Med (Biology of Exercise). May 15. pii: a029728. doi: 10.1101/cshperspect.a029728, 2017.  PMID: 28507192.  (Invited Review).

Casamento-Moran A, Hunter SK, Chen YT, Kwon MH, Fox EJ, Yacoubi B, Christou EA. Sex-differences in spatial accuracy relate to the neural activation of antagonistic muscles in young adults. Experimental Brain Research. Aug;235(8):2425-2436, 2017.PMID: 28500456

Lee A, Baxter J, Eischer C, Gage M, Hunter SK, Yoon T. Sex differences in neuromuscular function after repeated eccentric contractions of the knee extensor muscles. Eur J Appl Physiol, Jun;117(6):1119-1130.  PMID: 28432420.

Deering RE, Senefeld JW, Pashibin T, Neumann DA, Hunter SK. Muscle function and fatigability of trunk flexors in men and womenBiology of Sex Differences. Apr 17; 8:12, 2017. doi: 10.1186/s13293-017-0133-y. eCollection 2017. PMID: 28428836.

Kirking M, Berrios Barillas R, Nelson PA, Hunter SK, Hyngstrom AS. Sex differences in neuromuscular fatigue of the knee extensors post stroke Brain Sci  Jan 12;7(1). 2017.  PMCID: PMC5297297   DOI: 10.3390/brainsci7010008

Sundberg CW, Hunter SK, Bundle MW. Rates of performance loss and neuromuscular activity in men and women during cycling: evidence for a common metabolic basis of muscle fatigue. J Appl Physiol (1985). Jan 1;122(1):130-141, 2017.  doi: 10.1152/japplphysiol.00468.2016. PMID: 27856712

Senefeld J, Yoon T and Hunter SK.  Age differences in dynamic fatigability and variability of arm and leg muscles:  associations with physical function. Experimental Gerontology Jan; 87: 74–83, 2017. PMID: 27989926, PMCID: PMC5362345

2016

Hunter SK, Pereira HM, Keenan KG.  The aging neuromuscular system and motor performance. J Appl Physiol Oct 1;121(4):982-995, 2016.  doi: 10.1152/japplphysiol.00475.2016. Review. PMID: 27516536. PMCID: PMC5142309. (Invited Review).

Hunter SK. The relevance of sex differences in performance fatigability. Med Sci Sports Exerc. Nov;48(11):2247-2256, 2016 PMID: 27015385 (Invited Review).

Hunter SK, McNeil CJ, Butler JE, Gandevia SC, Taylor JL.  Short-interval cortical inhibition and intracortical facilitation during submaximal voluntary contractions changes with fatigue. Experimental Brain Research. Sep;234(9):2541-51, 2016. doi: 10.1007/s00221-016-4658-9. PMID: 27165508. PMCID: PMC5349854

Senefeld J, Smith C and Hunter SK.  Sex differences in participation, performance and the age of ultramarathon runners.International Journal of Sports Physiology and Performance Jul;11(7):635-42, 2016. doi: 10.1123/ijspp.2015-0418. PMID: 26561864

Senefeld J, Hunter SK. Molecular underpinnings of diabetic polyneuropathy. J Appl Physiol (1985). Jul 1;121(1), 360, 2016.  doi: 10.1152/japplphysiol.00380.2016. PMID: 27451278

Deaner RO, Addona V, Carter RE, Joyner MJ, Hunter SK. Fast men slow more than fast women in a 10 kilometer road race.  PeerJ. 2016 Jul 21;4:e2235. doi: 10.7717/peerj.2235. eCollection 2016. PMID: 27547544

Hunter SK. Sex differences in fatigability of dynamic contractions. Exp Physiol. Feb;101(2):250-5, 2016. doi: 10.1113/EP085370. PMID: 26440505. (Invited Review).

Senefeld J, Joyner MJ, Stevens AA and Hunter SK. Sex differences in elite swimming with advanced age are less than marathon running.  Scandinavian Journal of Medicine and Science in Sports.  Jan;26(1):17-28, 2016 PMID: 25648250

 

Studies

2019

  1. Sundberg CW, Prost RW, Fitts RH, Hunter SK. Bioenergetic basis for the increased fatigability with ageing. J Physiol. 2019 Apr 24. doi: 10.1113/JP277803. [Epub ahead of print]. PMID: 31018011
  2. Andsell P, Brownstein CG, Škarabot J, Hicks KM, Simoes D, Thomas K, Howatson G, Hunter SK, Goodall S.  Menstrual cycle associated modulations in neuromuscular function and fatigability of the knee extensors in eumenorrheic females. J Appl Physiol, published online Mar 7,2019. https://doi.org/10.1152/japplphysiol.01041.2018, PMID: 30844334
  3. Deering RE, Pashibin T, Cruz M, Hunter SK, Hoeger Bement M. Fatiguing trunk flexor exercise decreases pain sensitivity in postpartum women.  Frontiers in Physiology, Mar 26;10:315. doi: 10.3389/fphys.2019.00315. eCollection 2019.  PMID: 30971949 https://www.ncbi.nlm.nih.gov/pubmed/30971949
  4. Pereira HM, Schindler-Delap B, Keenan KG, Negro F, Farina D, Hyngstrom AS, Nielson KA, and Hunter SK. Oscillations in neural drive and age-related reductions in force steadiness with a cognitive challenge. J Appl Physiol, Apr 1;126(4):1056-1065, 2019.https://doi.org/10.1152/japplphysiol.00821.2018, PMID: 30817244
  5. Senefeld J, Limberg JK, Lukaszewicz KM and Hunter SK. Exercise-induced hyperemia is associated with knee extensor fatigability in adults with Type 2 diabetes. J Appl Physiol. Mar 1;126(3):658-667, 2019. PMID: 30605399.

2018

  1. Murphy SA, Negro F, Farina D, Onushko T, Durand M, Hunter SK, Schmit BD and Hyngstrom AS. Stroke increases ischemia-related decreases in motor unit discharge rates J Neurophysiol, 120: 3246 –3256, 2018. doi: 10.1152/jn.00923.2017. PMID: 30379629
  2. Pereira HM, Schlinder-Delap B, Nielson KA, Hunter SK. Force steadiness during a cognitively challenging motor task is predicted by executive function in older adults. Frontiers in Physiology 9(1316), 2018.
  3. Sundberg CW, Hunter SK, Trappe SW, Smith CS, Fitts R. Effects of elevated H+ and Pi on the contractile mechanics of skeletal muscle fibres from young and old men: implications for muscle fatigue in humans. J Physiol.  Sep;596(17):3993-4015, 2018.  PMID: 29806714 PMCID: PMC6117549.
  4. Deering RE, Senefeld JW, Pashibin T, Neumann DA, Cruz M, Hunter SK. Fatigability of the lumbopelvic stabilizing muscles in women 8 and 26 weeks postpartum.  Journal of Women's Health Physical Therapy. Sep-Dec;42(3):128-138. 2018. PMID: 30740039. PMCID: PMC6366649.
  5. Senefeld J, Magill SB, Harkins A, Harmer AR, Hunter SK. Mechanisms for the increased fatigability of the lower limb in people with Type 2 Diabetes. J Appl Physiol. Aug 1;125(2):553-566, 2018.  PMID: 29596017
  6. Deering RE, Cruz M, Senefeld JW, Pashibin T, Eickmeyer S, Hunter SK. Impaired trunk flexor strength, fatigability and steadiness in postpartum women. Med Sci Sports Exer. Aug;50(8):1558-1569, 2018.  PMID: 29554014.
  7. Sundberg CW, Kuplic A, Hassanlouei H, Hunter SK. Mechanisms for the age-related increase in fatigability of the knee extensors in old and very old adults. J Appl Physiol (1985). Jul 1;125(1):146-158, 2018. doi: 10.1152/japplphysiol.01141.2017 PMID: 29494293
  8. Keenan, KG, Senefeld JW & Hunter SK. Girls in the Boat: Sex Differences in Rowing Performance and Participation.  PLOS ONE.  Jan 19;13(1):e0191504. doi: 10.1371/journal.pone.0191504. eCollection 2018. PMID: 29352279.
  9. Senefeld JW, Pereira HM, Elliott N, Yoon T and Hunter SK. Sex differences in mechanisms of recovery after isometric and dynamic fatiguing tasks.  Med Sci Sports Exerc. 50(5):1070-108, 2018  PMID: 29298217, PMCID: PMC5899026

2017

  1. Rozand V, Senefeld JW, Hassanlouei H, Hunter SK. Voluntary activation and variability during maximal dynamic contractions with aging. Eur J Appl Physiol. Dec;117(12):2493-2507 2017. PMID: 29058113.

        https://www.ncbi.nlm.nih.gov/pubmed/29058113

  1. Andsell P, Thomas K, Howatson G, Hunter SK, Goodall S. Contraction intensity and sex differences in knee-extensor fatigability. J Electromyogr Kinesiol. Dec;37:68-74. 2017. doi: 10.1016/j.jelekin.2017.09.003.  PMID: 28963937
  2. Hassanlouei H, Sundberg W, Smith E, Kuplic A, and Hunter SK.  Physical activity modulates corticospinal excitability of the lower limb in young and old adults. J Appl Physiol, Aug 1;123 (2):364-374. DOI: 10.1152/japplphysiol.01078.20162017.PMCID: PMC5614787.
  3. Hunter SK. Performance Fatigability: Mechanisms and Task Specificity. Cold Spring Harb Perspect Med (Biology of Exercise).May 15. pii: a029728. doi: 10.1101/cshperspect.a029728, 2017.  PMID: 28507192.  (Invited Review).
  4. Casamento-Moran A, Hunter SK, Chen YT, Kwon MH, Fox EJ, Yacoubi B, Christou EA. Sex-differences in spatial accuracy relate to the neural activation of antagonistic muscles in young adults. Experimental Brain Research. Aug;235(8):2425-2436, 2017.PMID: 28500456
  5. Lee A, Baxter J, Eischer C, Gage M, Hunter SK, Yoon T. Sex differences in neuromuscular function after repeated eccentric contractions of the knee extensor muscles. Eur J Appl Physiol, Jun;117(6):1119-1130.  PMID: 28432420.
  6. Deering RE, Senefeld JW, Pashibin T, Neumann DA, Hunter SK. Muscle function and fatigability of trunk flexors in men and women Biology of Sex Differences. Apr 17; 8:12, 2017. doi: 10.1186/s13293-017-0133-y. eCollection 2017. PMID: 28428836.
  7. Kirking M, Berrios Barillas R, Nelson PA, Hunter SK, Hyngstrom AS. Sex differences in neuromuscular fatigue of the knee extensors post stroke Brain Sci Jan 12;7(1). 2017.  PMCID: PMC5297297   DOI: 10.3390/brainsci7010008
  8. Sundberg CW, Hunter SK, Bundle MW. Rates of performance loss and neuromuscular activity in men and women during cycling: evidence for a common metabolic basis of muscle fatigue. J Appl Physiol (1985). Jan 1;122(1):130-141, 2017.  doi: 10.1152/japplphysiol.00468.2016. PMID: 27856712
  9. Senefeld J, Yoon T and Hunter SK. Age differences in dynamic fatigability and variability of arm and leg muscles:  associations with physical function. Experimental Gerontology Jan; 87: 74–83, 2017. PMID: 27989926, PMCID: PMC5362345

2016

  1. Hunter SK, Pereira HM, Keenan KG.  The aging neuromuscular system and motor performance. J Appl Physiol Oct 1;121(4):982-995, 2016.  doi: 10.1152/japplphysiol.00475.2016. Review. PMID: 27516536. PMCID: PMC5142309. (Invited Review).
  2. Hunter SK. The relevance of sex differences in performance fatigability. Med Sci Sports Exerc. Nov;48(11):2247-2256, 2016 PMID: 27015385 (Invited Review).
  3. Hunter SK, McNeil CJ, Butler JE, Gandevia SC, Taylor JL.  Short-interval cortical inhibition and intracortical facilitation during submaximal voluntary contractions changes with fatigue. Experimental Brain Research. Sep;234(9):2541-51, 2016. doi: 10.1007/s00221-016-4658-9. PMID: 27165508. PMCID: PMC5349854
  4. Senefeld J, Smith C and Hunter SK. Sex differences in participation, performance and the age of ultramarathon runners.International Journal of Sports Physiology and Performance Jul;11(7):635-42, 2016. doi: 10.1123/ijspp.2015-0418. PMID: 26561864
  5. Senefeld J, Hunter SK. Molecular underpinnings of diabetic polyneuropathy. J Appl Physiol (1985). Jul 1;121(1), 360, 2016.  doi: 10.1152/japplphysiol.00380.2016. PMID: 27451278
  6. Deaner RO, Addona V, Carter RE, Joyner MJ, Hunter SK. Fast men slow more than fast women in a 10 kilometer road race. PeerJ. 2016 Jul 21;4:e2235. doi: 10.7717/peerj.2235. eCollection 2016. PMID: 27547544
  7. Hunter SK. Sex differences in fatigability of dynamic contractions. Exp Physiol. Feb;101(2):250-5, 2016. doi: 10.1113/EP085370. PMID: 26440505. (Invited Review).
  8. Senefeld J, Joyner MJ, Stevens AA and Hunter SK. Sex differences in elite swimming with advanced age are less than marathon running.  Scandinavian Journal of Medicine and Science in Sports. Jan;26(1):17-28, 2016 PMID: 25648250