Sleep, Circadian Rhythms, and Metabolism
B.A. Neuroscience, 2005, University of Virginia, Charlottesville
Ph.D. Neuroscience, 2011, Northwestern University, Evanston, IL
Postdoctoral Fellow, 2011-2014, University of Cincinnati,
Postdoctoral Fellow, 2014-2016, University of Michigan, Ann ArborI
Assistant Research Scientist, Department of Surgery, University of Michigan, Ann Arbor
BIOL 1510 Neuroscience for Non-Majors
BIOL 4702 Experimental Physiology
NRSC 8002 Neuroscience Foundations
BIOL 8931 Sleep and Circadian Rhythms
BIOL 8957 Seminar in Physiology
The Arble laboratory aims to advance basic and clinical science by exploring the relationships between sleep, breathing, circadian rhythms, and obesity. Using preclinical mouse models, our team studies key translational questions at the intersection of these fields using neuronal-targeting techniques, pharmacological manipulations, and behavioral assays. Some of our current research questions include:
- What are the neurobiological mechanisms that control sleep disordered breathing? How does obesity affect those mechanisms?
- How does the circadian system affect breathing?
- What are the metabolic outcomes of hypoxia at different times of day?
*indicates undergraduate student
- Framnes-DeBoer, S.N., Jones, A., Kang*, M., Propsom*, K., Nelson*, L., and Arble, D.M. (2021) The timing of intermittent hypoxia differentially affects macronutrient intake and energy substrate utilization in mice. Am J Physiol Endocrinol Metab. PubMedID# 34459217
- Jones, A.A., Nelson*, L., Marino*, G., Chappelle*, N., Joye, D.A. and Arble, D.M. (2021) Photoperiodic manipulation reveals a light-driven component to daily patterns of ventilation in C57Bl/6J mice. Journal of Biological Rhythms. PubMedID# 33685258
- Framnes-DeBoer, S.N., Bakke*, E., Yalamanchili*, S., Peterson*, H., Sandoval, D.A., Seeley, R.J., and Arble, D.M. (2020) Bromocriptine improves glucose tolerance independent of circadian timing, prolactin, or the melanocortin-4 receptor. Am J Physiol Endocrinol Metab. PubMedID# 31794265
- Arble, D. M., Schwartz, A., Polotsky, V., Sandoval, D.A., Seeley, R.J. (2019) Vertical sleeve gastrectomy improves ventilatory drive through a leptin-dependent mechanism. JCI Insights. PubMedID# 30626748
- Framnes, S.N. and Arble, D.M. (2018) The bidirectional relationship between obstructive sleep apnea and metabolic disease. Frontiers in Endocrinology. PubMedID# 30127766
- Flak, J.N., Arble, D., Pan, W., Patterson, C., Lanigan, T., Goforth, P.B., Sacksner, J., Joosten, M., Morgan, D., Allison, M.B., Hayes, J., Feldman, E., Seeley, R.J., Olson, D.P., Rahmouni, K., Myers Jr., M.G. (2017) A leptin-regulated neuronal circuit controls glucose mobilization during noxious stimuli. J Clin Invest. PubMedID# 28714862
- Arble, D. M., Ramsey, K. M., Bass, J. and Turek, F. W. 2010. Circadian disruption and metabolic disease: Findings from animal models. Best Pract Res Clin Endocrinol Metab 24(5), 785-800. PubMedID#21112026
- Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H. and Turek, F. W. (2009) Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring) 17(11), 2100-2102. PubMedID#19730426
Sarah Framnes-DeBoer (Ph.D. student)
Aaron Jones (Ph.D. student)
Dr. Arble is NOT currently accepting new Ph.D. students into her lab.