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miRDriver: A Tool to Infer Copy Number Derived miRNA-Gene Networks in Cancer
Banabithi Bose, Serdar Bozdag
Copy number aberration events such as amplifications and deletions in chromosomal regions are prevalent in cancer patients. Frequently aberrated copy number regions include regulators such as microRNAs (miRNAs). Identifying copy number-derived miRNA-target gene regulatory interactions in cancer could shed some light on biological mechanisms in tumor initiation and progression. In the present study, we developed a computational pipeline, called miRDriver which is based on the hypothesis that copy number data from cancer patients can be utilized to discover driver miRNAs of cancer. Read more about Banabithi's research.