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A Celebration of Research Featured Presenter

Intermittent Hypoxia Causes Cardiometabolic Dysfunction in Obese, ob/ob Mice
Sarah Framnes-DeBoer, Aaron Jones, Deanna Arble

It is unclear if it is leptin insensitivity or other aspects of obesity that make individuals more susceptible to cardiometabolic diseases when experiencing intermittent hypoxia in the form of Obstructive sleep apne. To determine the relative involvement of leptin and/or obesity in the cardiometabolic outcomes of intermittent hypoxia, we exposed lean C57Bl/6J WT mice, leptin-deficient ob/ob mice, and weight-restricted ob/ob mice to 6 days of IH. Read more about the group's research.