Dr. Edward Blumenthal

Dr. Edward BlumenthalMarquette University

Wehr Life Sciences, 504

MilwaukeeWI53201United States of America(414) 288-6270edward.blumenthal@marquette.edu

e-Publications

Associate Professor

Genetics of Animal Function

Education

B.A. (Biochemistry), 1987, Cornell University, Ithaca, NY
Ph.D. (Neuroscience), 1993, Yale University, New Haven, CT
Postdoctoral Fellow, University of California-San Diego, CA
Postdoctoral Fellow, University of Virginia, Charlottesville, VA

Courses Taught

Research Interests

https://www.blumenthallab.org/

Professional Affiliations

Genetics Society of America
The American Physiological Society

Publications

Sheahan T.D., A. Grewal, L.E. Korthauer, and E.M. Blumenthal. 2023. The Drosophila drop-dead gene is required for eggshell integrity. PLoS One 18(12): e0295412. doi: 10.1371/journal.pone.0295412

Conway, S., Sansone, C.L., Benske, A., Kentala, K., Billen, J., Vanden Broeck, J., and Blumenthal, E.M.  2018.  Pleiotropic and novel phenotypes in the Drosophila gut caused by mutation of drop-dead.  Journal of Insect Physiology 105: 76-84. doi: 10.1016/j.jinsphys.2018.01.007

Zhang, H. and E.M. Blumenthal.  2017.  Identification of multiple functional receptors for tyramine on an insect secretory epithelium.  Scientific Reports 7(1):168. doi: 10.1038/s41598-017-00120-z.

Cabrero, P., S. Terhzaz, M. F. Romero, S. A. Davies, E. M. Blumenthal, and J. A. Dow. 2014. Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis." Proceedings of the National Academy of Sciences USA 111.39: 14301-6. 10.1073/pnas.1412706111.

Sansone, C.L. and E.M. Blumenthal.  2013.  Neurodegeneration in drop-dead mutant Drosophila melanogaster is associated with the respiratory system but not with hypoxia.  PLoS One, 8.7:e68032. doi:10.1371/journal.pone.0068032.

Ruka, K.A., A.P. Miller, and E.M. Blumenthal. 2013. Inhibition of diuretic stimulation of an insect secretory epithelium by a cGMP-dependent protein kinase. American Journal of Physiology: Renal Physiology, 304.9:F1210-6. doi:10.1152/ajprenal.00231.2012

Sansone, C.L. and E.M. Blumenthal.  2012.  Developmental expression of drop-dead is required for early adult survival and normal body mass in Drosophila melanogaster.  Insect Biochemistry and Molecular Biology, 42.9:690-8. doi:10.1016/j.ibmb.2012.06.002.

Honors and Awards

2011-12 Senior Research Fellowship, KU Leuven, Leuven Belgium

Grants

2014-2019 Regulation of epithelial barrier formation in Drosophila.  NSD IOS-1355087

2012-2015 REU Site: Undergraduate Summer Research in Molecular and Cellular Biology. NSF DBI-1156569

2008-2013 Characterization of tyramine-mediated cell-cell communication in the Drosophila Malpighian tubule.  NSF IOS-0744619

2007-2010 Characterization of a mutation that affects feeding and digestion in Drosophila. NIGMS R15-GM080682

2001-2003 Identification of osmoregulatory mutants in Drosophila.  NIDDK R21-DK080680

Presentations

drop-dead mutants show early neuronal apoptosis and subsequent hyperactivation of all innate immune markers. The Allied Genetics Conference 2024. National Harbor, MD. March 6-10, 2024. (Presented by U. Jhuti)

Investigating the relationship between drop-dead (drd) expression in the cardia and peritrophic matrix (PM) formation in Drosophila melanogaster. Midwest Drosophila Conference. Monticello, IL. November 16-17, 2024. (Presented by M. Maciulewicz)

Effect of drop-dead mutation on the integrity of the cortex glial network in Drosophila pupal brains. Midwest Drosophila Conference. Monticello, IL. November 16-17, 2024. (Presented by G. Ghiselli)

drop-dead mutants show altered cortex glial (CG) morphology and age-dependent hyperactivation of innate immunity (HII). 64th Annual Drosophila Research Conference. Chicago, IL. March 1-5, 2023. (Presented by U. Jhuti)

Mechanism of adult neurodegeneration in drop-dead mutants. 63rd Annual Drosophila Research Conference. San Diego, CA. April 6-10, 2022. (Presented by U. Jhuti)

Regulation of extracellular barrier integrity by the drop-dead gene in Drosophila melanogaster.  1^st International Molecular Plant Protection Congress.  Adana, Turkey.  April 10-13, 2019. (Invited keynote speaker).

Regulation of larval growth by drop-dead.  60^th Annual Drosophila Research Conference.  Dallas, TX.  March 27-31, 2019. (Presented by L. Hopson)

Students

Dr. Blumenthal is currently accepting new Ph.D. students into his lab

Current Students

Danny Hodell (Ph.D. student)